Aerobic Interval Training in Patients With Paroxysmal or Persistent Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Change in burden of atrial fibrillation
研究概览
简要总结
The purpose of this study is to determine the effect of aerobic interval training in patients with paroxysmal or persistent atrial fibrillation, especially to see if the burden of atrial fibrillation and symptoms are reduced.
详细描述
Long term endurance sport practice is associated with a higher incidence of atrial fibrillation. Moderate/light physical activity seems to be associated with a lower incidence. The underlying mechanisms are uncertain. In order to examine the effect of training in this population, the investigators will perform a randomised controlled study with aerobic interval training in patients with paroxysmal/persistent atrial fibrillation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with paroxysmal or persistent atrial fibrillation, that are able to perform aerobic interval training.
排除标准
- •Performing high intensity training (pulse >90% of max) for more than 2 times a week.
- •Moderate intensity training more than 30 min, more than 3 times a week
- •Previous open heart surgery
- •Significant aorta stenosis
- •Mitral insufficiency, >gr. 2
- •Pacemaker
- •Earlier coronary intervention and not complete revascularization
研究组 & 干预措施
Interval training
Interval training
干预措施: Interval training (Behavioral)
Control
Live as usual
结局指标
主要结局
Change in burden of atrial fibrillation
时间窗: Baseline and 4 weeks after ended intervention period
Burden of atrial fibrillation(number of episodes, duration(percent of the day)) continually measured, and reported by the patient. Analysed for the patients in total, with sub analysis in the groups of paroxysmal and persistent AF and in those with a low burden of atrial fibrillation vs. those with a larger burden.
次要结局
- Size of left atrium and ventricle(Baseline and after ended intervention period(12 weeks))
- Blood samples(Baseline and after ended intervention period(12 weeks))
- Endothelial function(Baseline and after ended intervention period(12 weeks))
- Atrial extrasystoles(Baseline and after ended intervention period(12 weeks))
- Ablation procedure(Measured during the ablation procedure (day 1))
- Maximal oxygen uptake(Baseline and after ended intervention period(12 weeks))
- Atrial and ventricular function(Baseline and after ended intervention period(12 weeks))
- Fibrosis(Baseline and after ended intervention period(12 weeks))
- Quality of life(Baseline and after ended intervention period(12 weeks))
- Burden of atrial fibrillation in the intervention period(Week 1-4, 5-8 and 9-12)