Comparing the effects of intravenous Lignocaine and Ketamine on postoperative pain after Ear, Nose and Throat surgeries.

Phase 3

Not yet recruiting

Brief Summary: Adequate post operative pain management is an essential part of perioperative care because postoperative pain causes patient discomfort and may reduce patient satisfaction. More importantly, it can increase the risk for pulmonary and cardiovascular complications and may even lead to the onset of chronic pain. Rates of absence from work for more than 2 weeks following routine ENT surgery and rates of readmission or overstay after nasal surgery are more than 10% suggesting that this patient group cannot be neglected. Pain levels experienced by patients who have undergone an ENT procedure are probably underestimated. Recently there is a growing interest in the use of different analgesic adjuncts like intravenous infusion of local anesthetics (eg, Lignocaine) and NMDA receptor antagonist (eg, Ketamine). Lignocaine is a local anesthetic which mainly acts as a voltage-gated sodium channel blocker and has analgesic, anti-hyperalgesic and anti-inflammatory properties. Ketamine has good analgesic properties and prevents the development of central sensitization, hyperalgesia and opioid resistance when administered in sub-anesthetic doses. Recent studies in this field have shown mixed results and there is paucity of research trials on post-operative pain in ENT surgeries hence, this study was planned.

Recruitment & Eligibility

Inclusion Criteria

ASA class I and II.

Exclusion Criteria

Patients requiring postoperative mechanical ventilation or regional analgesia Patients on perioperative gabapentin, magnesium Pregnant or breastfeeding mothers BMI more or equal to 35kh/sq meter Allergy or contraindications to study medications.
Patients with cardiac, renal or hepatic disease.
Patients with seizure or other neurological disorder.
Patients with chronic preoperative opioid use or substance abuse and history of chronic pain.

Primary Outcome Measures

Name	Time	Method
Pain assessed post operatively	Assessment of pain immediately post op, \| 1hour, \| 6hour, \| 12hour and \| 24hour.

Secondary Outcome Measures

Name	Time	Method
First & total rescue analgesia (paracetamol) consumed	24 hours post-operatively.

Locations (1): Karnataka institute of medical sciences
🇮🇳
Dharwad, KARNATAKA, India
Karnataka institute of medical sciences
🇮🇳Dharwad, KARNATAKA, India
Dr Ashwini H R
Principal investigator
9480553670
ashvenki.hubli@gmail.com