ICEBERG STUDY. Respiratory Mechanics Assessment During Assisted Mechanical Ventilation

University of Milano Bicocca8 sites in 5 countries298 target enrollmentSeptember 1, 2021

ConditionsAcute Hypoxemic Respiratory Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Hypoxemic Respiratory Failure
Sponsor: University of Milano Bicocca
Enrollment: 298
Locations: 8
Primary Endpoint: Correlation between respiratory system mechanical properties and ICU mortality
Status: Completed
Last Updated: 11 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and ICU mortality.

Registry

clinicaltrials.gov

Start Date

September 1, 2021

End Date

June 3, 2023

Last Updated

11 months ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Milano Bicocca

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Acute Hypoxaemic Respiratory Failure (defined as respiratory failure requiring invasive mechanical ventilation with a PaO2/FiO2\< 300 mmHg) during the course of ICU stay (including ARDS).
•Invasive mechanical ventilation in one of these modes: Pressure A/C, PRVC, SIMV PC, PSV, NAVA, PAV+, BiPAP
•Presence of spontaneous breathing activity (ventilator triggering), since 6 hours and no longer than 48 hours
•Patient for full active management at this point.

Exclusion Criteria

•Age \<18 years old
•Pregnancy
•Active air leaks
•Moribund state
•Patient has passed a spontaneous breathing trial (if performed for clinical indication)
•Known COPD with history of home oxygen therapy and/or non invasive ventilation and/or GOLD III-IV. Non invasive ventilation for sleep apnea is NOT an exclusion criteria.