NCT05203536已完成不适用
ICEBERG STUDY. Respiratory Mechanics Assessment During Assisted Mechanical Ventilation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 298
- 试验地点
- 8
- 主要终点
- Correlation between respiratory system mechanical properties and ICU mortality
研究概览
简要总结
To verify the association between respiratory system mechanical properties (ΔP, ΔPL,dyn, Pmus, Pplat and CRS and CL,dyn) assessed during assisted modes of ventilation (as average over the first three days since enrollment) and ICU mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute Hypoxaemic Respiratory Failure (defined as respiratory failure requiring invasive mechanical ventilation with a PaO2/FiO2< 300 mmHg) during the course of ICU stay (including ARDS).
- •Invasive mechanical ventilation in one of these modes: Pressure A/C, PRVC, SIMV PC, PSV, NAVA, PAV+, BiPAP
- •Presence of spontaneous breathing activity (ventilator triggering), since 6 hours and no longer than 48 hours
- •Patient for full active management at this point.
排除标准
- •Age <18 years old
- •Pregnancy
- •Active air leaks
- •Moribund state
- •Patient has passed a spontaneous breathing trial (if performed for clinical indication)
- •Known COPD with history of home oxygen therapy and/or non invasive ventilation and/or GOLD III-IV. Non invasive ventilation for sleep apnea is NOT an exclusion criteria.
结局指标
主要结局
Correlation between respiratory system mechanical properties and ICU mortality
时间窗: 90 days
Difference between mean values of driving pressure in survivors and non-survivors at ICU discharge.
次要结局
- Correlation between respiratory system compliance and ICU mortality(90 days)
- Correlation between pressure muscle index and ICU mortality(90 days)
- Correlation between plateau pressure and ICU mortality(90 days)
- Correlation between muscle pressure and ICU mortality(90 days)
研究者
研究点 (8)
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