The effect of chickpea structures on glucose response and appetite regulatio

Not Applicable

• Conditions: Digestion in healthy participants; Digestive System

• Registration Number: ISRCTN18097249
• Lead Sponsor: Imperial College London

Brief Summary

2022 Thesis results in https://spiral.imperial.ac.uk/bitstream/10044/1/101773/2/Olotu-O-2022-MDR-MRes-Thesis.pdf (added 10/08/2023)

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-11
• Last Update Posted: 24 June 2024
• Study Completion: 2024-08-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

1. Age between 18 - 65 years (inclusive)
2. Body mass index (BMI) of 18-30 kg/m²
3. Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements

Exclusion Criteria

1. Abnormal ECG
2. Screening blood results outside of normal reference values
3. Weight change of = 5kg in the preceding 2 months
4. Current smokers
5. History of substance abuse and/or excess alcohol intake • Pregnancy • Diabetes • Cardiovascular disease
6. Cancer
7. Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
8. Kidney disease
9. Liver disease
10. Pancreatitis
11. Started new medication within the last 3 months likely to interfere with energy metabolism, appetite regulation and hormonal balance, including anti-inflammatory drugs or steroids, antibiotics, androgens, phenytoin, erythromycin or thyroid hormones
12. Participation in a research study in the 12 week period prior to entering this study
13. Any blood donation within the 12 week period prior to entering this study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Appetite-regulating gut hormones measured using RIA assay in the intestinal contents that will be collected through a nasoenteric tube at 0, 60, 120, 180, 240, 300, 420, 480 min at each study day

Secondary Outcome Measures

Name	Time	Method
1. Circulating concentrations of glucose, insulin, and metabolites measured using ci8200 analyser enzymatic method, RIA assay, and GC-MS respectively at 0, 60, 120, 180, 240, 300, 420, 480 min at each study day<br>2. Subjective measures of appetite, as assessed by Visual Analogue Scales (VAS) at 0, 60, 120, 180, 240, 300, 420, 480 min at each study day<br>3. Energy intake as determined by an ad libitum meal at 240 min at each study day