Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Other: No specific intervention for this study

• Registration Number: NCT02284932
• Lead Sponsor: Laval University

Brief Summary

Limb muscle dysfunction, characterized by atrophy and weakness, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.

One prevailing hypothesis stipulates that the deterioration in muscle structure and function during COPD results from a spillover of inflammatory mediators from the lungs to the systemic circulation and then to the muscles.

Detailed Description

The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle atrophy. Moderate to severe COPD patients (FEV1 under 60% of predicted) and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity, muscle force and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins of signaling intramuscular pathways involved in protein synthesis and degradation will be measured in the quadriceps.

Study Timeline

• Study Start: 2011-09
• Study First Submitted: 2014-10-08
• Study First Submitted QC: 2014-11-05
• Study First Posted: 2014-11-06
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-07
• Last Update Posted: 2016-09-08
• Primary Completion: 2017-09
• Study Completion: 2018-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 36

Inclusion Criteria

• male
• COPD with an FEV1 of under 60% of predicted
• non-smoker
• between 55 and 75 years old

Exclusion Criteria

• all inflammatory disease (HIV, cancer, renal and cardiac deficiency)
• hormonal dysregulation
• inferior limb pathology
• neuromuscular pathology
• history of tobacco or alcool abuse
• oxygen dependent
• recent exacerbation (2 months) of the symptoms of COPD

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
COPD patients	No specific intervention for this study	Group : COPD patients No specific intervention for this study
Healthy controls	No specific intervention for this study	Group : healthy volunteers No specific intervention for this study

Primary Outcome Measures

Name	Time	Method
Decrease of protein degradation in muscles of wasted COPD patients	At baseline (COPD in a stable state of the disease)

Secondary Outcome Measures

Name	Time	Method
Increase of protein synthesis in muscles of wasted COPD patients	At baseline (COPD in a stable state of the disease)

Trial Locations

Locations (1)

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec; 🇨🇦 Quebec, Canada