Muscle Atrophy In Patients With Chronic Obstructive Pulmonary Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Laval University
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Decrease of protein degradation in muscles of wasted COPD patients
- Last Updated
- 9 years ago
Overview
Brief Summary
Limb muscle dysfunction, characterized by atrophy and weakness, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.
One prevailing hypothesis stipulates that the deterioration in muscle structure and function during COPD results from a spillover of inflammatory mediators from the lungs to the systemic circulation and then to the muscles.
Detailed Description
The investigators objective is to investigate the impact of COPD on key signaling pathways involved in the muscle atrophy. Moderate to severe COPD patients (FEV1 under 60% of predicted) and healthy controls will be recruited. All of the investigators patients will undergo a thorough baseline assessment in pulmonary capacity, muscle force and body composition. Blood sampling and biopsy of the quadriceps will be done. Key proteins of signaling intramuscular pathways involved in protein synthesis and degradation will be measured in the quadriceps.
Investigators
Annie Dubé
Professionelle de recherche
Laval University
Eligibility Criteria
Inclusion Criteria
- •COPD with an FEV1 of under 60% of predicted
- •non-smoker
- •between 55 and 75 years old
Exclusion Criteria
- •all inflammatory disease (HIV, cancer, renal and cardiac deficiency)
- •hormonal dysregulation
- •inferior limb pathology
- •neuromuscular pathology
- •history of tobacco or alcool abuse
- •oxygen dependent
- •recent exacerbation (2 months) of the symptoms of COPD
Outcomes
Primary Outcomes
Decrease of protein degradation in muscles of wasted COPD patients
Time Frame: At baseline (COPD in a stable state of the disease)
Secondary Outcomes
- Increase of protein synthesis in muscles of wasted COPD patients(At baseline (COPD in a stable state of the disease))