Comparative Study Between Conventional Fasting Versus Overnight Infusion of Lipid or Carbohydrate on Free Fatty Acid and Insulin in Obese Patients Undergoing Elective First Time On-pump Coronary Artery Bypass Grafting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 主要终点
- The change in free fatty acids levels and insulin blood levels before and after the infusion of study solution
研究概览
简要总结
Comparative study between conventional fasting versus overnight infusion of lipid or carbohydrate on free fatty acids and insulin in obese patients undergoing elective first time on-pump coronary artery bypass grafting.
详细描述
Obese patients scheduled for bypass surgery randomly assigned to three groups:
Group I (Glucose-group): patients received 500 cc of glucose 10% containing 50 g of glucose and providing patients with 200 Kcal with an osmolarity of 556 mosm/L.
Group II (Lipid-group): patients received 100 cc of lipid solution (soybean 30%, medium chain triglycerides 30%,olive oil 25%,fish oil 15% and 20 mg vitamine E) containing 20 g lipid and provides patients with 200 Kcal with an osmolarity of 380 mosm/L.
Group III (Control-group): patients fasted overnight from 11 pm till 9 am except for clear fluids which were allowed till 5 am.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (> 18 years) with American Society of Anesthesia (ASA) class II-III, BMI 30-40, and New York Heart Association (NYHA) functional capacities I-II, undergoing elective on-pump coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB).
- •All patients were type 1a World Health Organisation (WHO)/Fredrickson classification of primary hyperlipidemias.
排除标准
- •Patients with diabetes mellitus
- •Patients on fibrates
- •Patients type 1,2b,3,4 and 5 WHO/Fredrickson classification of primary hyperperlipidemias
- •Patients with history of allergic reactions to fish, egg yolk containing foods peanut or soy products
- •Patients with carbohydrate or fat intolerance
结局指标
主要结局
The change in free fatty acids levels and insulin blood levels before and after the infusion of study solution
时间窗: Over an infusion period of 10 hours preoperatively
次要结局
未报告次要终点
研究者
Hisham Hosny
assistant professor
Cairo University