Comparing the impact of acute vigorous intensity or moderate intensity exercise with rest, on airway and systemic inflammation, oxidative stress and antioxidants in adults with asthma: a randomised controlled trial

Dr Hayley Scott0 个研究点目标入组 56 人开始时间: 2015年3月27日最近更新: 2021年12月27日

适应症

试验速览

暂无简介。

•1.Physician diagnosed asthma
•2.Able to provide written informed consent
•3.Females 18-55 years of age or males 18-45 years of age
•4.Body mass index (BMI) <=40kg/m2
•5.Not a current smoker (never smoker or quit at least 6 months ago)
•6.Post-bronchodilator forced expiratory volume in 1 second (FEV1) >=50% predicted.
•7.Approved for vigorous exercise by the study coordinator, according to the ESSA Adult Pre-Exercise Screening Tool”.

•1.Asthma is not the primary respiratory diagnosis
•2.A moderate exacerbation (oral corticosteroid or antibiotic use) in the past four weeks or severe exacerbation (hospitalisation) in the past three months
•3.Participation in a moderate-vigorous intensity exercise session within 2 days of the scheduled study visit.
•4.Known cardiac condition
•5.Musculoskeletal contraindication to exercise
•6.Uncontrolled hypertension (blood pressure >180/100mmHg)
•8.Diabetes mellitus
•9.Thyroid disorder
•10.Taking cholesterol lowering medication or ß-blocker medication
•11.Pregnancy or breastfeeding
•12.Resting SpO2 <=95% on room air
•13.Participation in an interventional research study in the last four weeks
•14.Currently exercising at a moderate-intensity or greater for >90 mins/week
•15.Subject has a clinically important medical illness (including serious psychological disorders) likely to interfere with management or participation in the study

发起方

Dr Hayley Scott