A clinical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in CABG patients
Completed
- Conditions
- cardiovascular disease - heart disease1001108210007593
- Registration Number
- NL-OMON36080
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 46
Inclusion Criteria
- Patients who have to undergo first time elective on-pump CABG without valve surgery
- older than 18 years
Exclusion Criteria
- Diabetes or representing with hyperglycaemia (glucose > 8mM)
- increased preoperative cardiac troponin T values
- Unstable angina or angina within 48 hours before infarction
- Concomitant procedures
- Ejection fraction < 40%
- severe COPD
- SaO2 < 90% at room temperature
- Peripheral vascular disease affecting the upper limbs
- Nicorandil use
- Pre-/peri-operative morphin use
- women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters are the HK mitochondrial binding ratio and<br /><br>cardioprotection, evaluated by plasma cardiac troponin T (cTnT) values.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary parameters are cytokine (IL-6, IL-10 and TNF-a) levels and inotropic<br /><br>score. Furthermore CRP will be determined at the same time points as cTnT.</p><br>