TCTR20221207001已完成3 期
Spironolactone to Prevent Progression of Vascular Calcification in Peritoneal Dialysis Patients: A Randomized Controlled Trial
avamindrahiraj University Research Fund0 个研究点目标入组 40 人开始时间: 2022年12月7日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
Among peritoneal dialysis patients, spironolactone showed a potential benefit to prevent the progression of vascular calcification. Further studies with a larger population and long-term follow-up should be conducted.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1. aged 18-80 years
- •2. end-stage renal disease receiving peritoneal dialysis.
排除标准
- •(1) patients who currently receive spironolactone within 3 months
- •(2) persistent hyperkalemia (defined as average serum potassium >5.5 mEq/L within 3 months)
- •(3) persistent hypotension (defined as systolic blood pressure <90 mmHg and diastolic blood pressure <60 mmHg without other antihypertensive drugs)
- •(4) persistent hyperphosphatemia (defined as average serum phosphate >5.5 mg/dL within 3 months)
- •(5) hyperparathyroidism (defined as serum intact PTH >585 pg/mL)
- •(6) dialysis vintage >10 years
- •(7) life expectancy <1 year due to active malignancy, infection or other diseases
- •(8) pregnancy or lactation female
- •(9) post kidney transplant or kidney transplant candidate within 1 year.
研究者
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