CTIS2024-510892-40-00
Active, not recruiting
Phase 1
Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients with Cardiogenic Shock from Acute Myocardial Infarction - NORshock
Amsterdam UMC0 sites776 target enrollmentJanuary 16, 2024
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Acute myocardial infarction complicated by cardiogenic shock
- Sponsor
- Amsterdam UMC
- Enrollment
- 776
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute myocardial infarction, STEMI or NSTEMI, Early revascularization by PCI, Cardiogenic shock, characterized by: I. a. Systolic blood pressure (SBP) \< 90 mmHg for \> 30 minutes, OR b. Use of drugs to maintain SBP \> 90 mmHg at presentation before randomization. II. Clinical signs of impaired organ perfusion with at least one of the following criteria: a. Altered mental status b. Cold, clammy skin and extremities c. Oliguria with urine output \< 30ml/hour d. Serum lactate \> 2\.0 mmol/L III. Clinical signs of pulmonary congestion
Exclusion Criteria
- •Resuscitation \> 30 minutes, Mechanical cause of cardiogenic shock (e.g. papillary muscle rupture, ventricular septal rupture), Onset of shock \> 12 hours, Imminent need for mechanical circulatory support, Women \< 45 years
Outcomes
Primary Outcomes
Not specified
Similar Trials
Active, not recruiting
Phase 1
Outcomes for people with cardiogenic shock after myocardial infarction by comparing two blood pressure targets.Myocardial infarction related cardiogenic shockTherapeutic area: Diseases [C] - Cardiovascular Diseases [C14]EUCTR2021-005551-36-DKAmsterdam University Medical Center, AMC776
Active, not recruiting
Phase 1
Outcomes for people with cardiogenic shock after myocardial infarction by comparing two blood pressure targets.Myocardial infarction related cardiogenic shockTherapeutic area: Diseases [C] - Cardiovascular Diseases [C14]EUCTR2021-005551-36-NL776
Recruiting
Phase 4
Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients with Cardiogenic Shock from Acute Myocardial Infarction: A Multicenter Randomized TrialNL-OMON56427Cardiologie776
Active, not recruiting
Not Applicable
Testing the effectiveness of a multicomponent frailty management program in SingaporeFrailtyFallsPhysical Medicine / Rehabilitation - Other physical medicine / rehabilitationACTRN12621001673831Singapore Institute of Technology116
Completed
Not Applicable
Clinical Outcome and Cost-effectiveness of Routine Follow-up Coronary Angiography after Percutaneous Coronary stenting in JapaCoronary artery diseaseJPRN-UMIN000039768The University of Tokyo558