Hereditary breast cancer and the clinical significance of variants in the BRCA1 and BRCA2 genes. - Hereditary breast cancer and DNA Unclassified Variants.

eids Universitair Medisch Centrum0 个研究点目标入组 270 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•1) UV-cohort: patients who are carrier of an unclassified variant.
•2) Affected relatives of the UV-cohort patients will be invited for this study.
•3) At least one non-affected family member of the UV-cohort patients will be invited to take part in this study. ;The UV-cohort consists of patients diagnosed with a primary breast tumor before the age of 60 years and are unrelated.
•The patient can be included if only one unclassified variant is found in the BRCA1 or BRCA2 gene.
•All the participants should be older than 18 years, competent and independent of the researcher.
•They should all be informed about the study, its goal and its duration.
•They know about the possibility of interim quitting the study.

•- Younger than 18 years old and older than 60 years old. Not affected family members may however, be older than 60 years old.
•-The participants should be competent to be able to make decision about participation.

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