Cisplatin and Sodium Thiosulfate Otoprotection With or Without SAHA/Vorinostat Histone Deacetylase Inhibition for Relapsed/Refractory Hepatoblastoma and Other Embryonal Tumors

Children's Hospital Medical Center, Cincinnati1 site in 1 country33 target enrollmentMarch 1, 2023

ConditionsOtotoxicity, Drug-Induced

InterventionsSodium Thiosulfate

DrugsSodium Thiosulfate

Overview

Phase: Early Phase 1
Intervention: Sodium Thiosulfate
Conditions: Ototoxicity, Drug-Induced
Sponsor: Children's Hospital Medical Center, Cincinnati
Enrollment: 33
Locations: 1
Primary Endpoint: Prevention of hearing loss
Status: Suspended
Last Updated: 6 months ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This study will attempt to demonstrate the efficacy of Sodium Thiosulfate (STS) in preventing hearing loss in patients re-treated with cisplatin-based therapy according to regimens Cisplatin and STS (regimen CS) and Cisplatin, STS and Vorinostat/SAHA (regimen CSS).

Detailed Description

This trial will assess the effect of STS in preventing subsequent hearing loss when patients are re-challenged with cisplatin therapy at relapse/progression, as well as the efficacy of cisplatin/STS or cisplatin/STS/SAHA for patients with relapsed hepatoblastoma, Wilms, Germ Cell Tumor (GCT) and Neuroblastoma stratified by initial cisplatin sensitivity. Important pharmacokinetic measurements focused on cisplatin and STS in children, with varying degrees of renal function, will be assessed. Such pharmacokinetic data will fill a current gap in our clinical knowledge base and enable safer use of such agents for all children with such cancers, regardless of kidney function, in the future.

Registry

clinicaltrials.gov

Start Date

March 1, 2023

End Date

January 1, 2027

Last Updated

6 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Children's Hospital Medical Center, Cincinnati

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients must be \> 1 month and ≤ 39 years old at study enrollment
•Histologically proven, at time of diagnosis or relapse:
•Stratum 1: Arm CS (Cisplatin/STS): Previously chemosensitive to cisplatin defined as an AFP drop of 1 log (90%) and/or an objective tumor response of 30% or greater on imaging while receiving cisplatin.
•Stratum 2A: Cisplatin/STS/SAHA (CSS): Previously chemosensitive but with noted subsequent progression on cisplatin or initially chemoresistant to cisplatin (all other hepatoblastoma patients). Resistance to cisplatin is defined as rising alpha-fetoprotein (AFP) x 2 consecutive measurements or imaging progression including growth of known lesions or new lesions while patient is receiving a cycle of chemotherapy containing cisplatin or relapse noted within 3 months of last cisplatin administration.
•Stratum 2B: CSS: Relapsed/refractory Wilms tumor, Germ Cell Tumor, or Neuroblastoma
•Patients must have a life expectancy of ≥ 8 weeks.
•Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study:
•Myelosuppressive chemotherapy: Must not have received within 2 weeks of entry onto this study. Previous SAHA administration is permitted. Tacrolimus and Sirolimus with levels \<= 10 ng/ml are not considered myelosuppressive.
•Immunotherapy: Must not have received within 2 weeks of entry onto this study.
•Radiation therapy (RT): greater than or equal to 2 weeks for local palliative RT (small port); greater than or equal to 6 months must have elapsed if prior craniospinal RT or if greater than or equal to 50% radiation of pelvis

Exclusion Criteria

•Patients with any uncontrolled, intercurrent illness including, but not limited to, uncontrolled infection
•Patients with symptomatic congestive heart failure (defined as Grade 2 or higher heart failure per CTCAE version 5.0)
•Patients with Renal Tubular Acidosis (RTA) as evidenced by serum bicarbonate \< 16 mmol/L and serum phosphate ≤ 2 mg/dL (or \< 0.8 mmol/L) without supplementation. Patients requiring electrolyte supplementation for RTA will be permitted if bicarbonate ≥16 mmol/L and phosphate \> 2mg/dL after at least 7 days of stable supplementation regimen
•Pregnancy and Breastfeeding:
•Female patients who are pregnant or breast-feeding will not be entered in the study. A negative pregnancy test within 72 hours of starting therapy is required for female patients of childbearing potential
•Lactating females who plan to breastfeed their infants.
•Sexually active patients of reproductive potential must agree to use an effective contraceptive method for the duration of their study participation
•Patients on tacrolimus and/or sirolimus with levels of either targeted \> 10 ng/mL
•Known allergy to any component of CS or CSS therapy, as indicated

Arms & Interventions

Stratum 1- Regimen CS

Cisplatin sensitive/no progression on cisplatin (when given at first diagnosis)

Intervention: Sodium Thiosulfate

Stratum 2A- Regimen CSS

Cisplatin resistant or progressed on cisplatin after initial response (when given at first diagnosis)

Intervention: Sodium Thiosulfate

Stratum 2B- Regimen CSS

Wilms tumor, GCT, Neuroblastoma

Intervention: Sodium Thiosulfate

Outcomes

Primary Outcomes

Prevention of hearing loss

Time Frame: Through study completion up to 5 years

To demonstrate the efficacy of Sodium Thiosulfate (STS) in preventing hearing loss in patients re-treated with cisplatin-based therapy according to regimens Cisplatin/STS (CS) and Cisplatin/STS/SAHA (CSS)

Secondary Outcomes

Prevention of hearing loss and tumor reduction(Through study completion up to 5 years)
Number of Participants with Treatment-Related Adverse Events(Through study completion up to 5 years)
Stratum 1 efficacy(Through study completion up to 5 years)
Stratum 2 efficacy(Through study completion up to 5 years)
Maximum Plasma Concentration [Cmax](Through study completion up to 5 years)