Association Between Postoperative Cerebral Vascular Complication and Functional Prognosis and Cerebral Small Vascular Disease (CSVD) After Thoracic Surgery : an Exploratory Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebral Small Vessel Diseases
- Sponsor
- RenJi Hospital
- Enrollment
- 212
- Locations
- 1
- Primary Endpoint
- Incidence of postoperative overt stroke
- Last Updated
- 3 years ago
Overview
Brief Summary
The investigators perform a retro-prospective exploratory cohort study among patients 65 to 85 years old with pre-operative head MRI result after thoracic surgery in Renji Hospital Affiliated to Shanghai Jiaotong University from November 2020 to December 2021. Perioperative data were collected, including preoperative general condition, laboratory examination, auxiliary examination (blood routine, blood coagulation, liver and kidney function, etc.), perioperative indicators （use of anesthetics, anesthetic time, blood pressure, etc.）, postoperative cerebral function follow-up and occurrence of cerebral vascular complications (brain infarction, brain bleed, etc.) of patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •65≤age\<85
- •after thoracic surgery
- •finish pre-operative brain MRI
Exclusion Criteria
- •mental illness
- •existing dementia and other diseases: Alzheimer disease, dementia, Parkinson's disease, Huntington's disease, systemic lupus erythematosus, etc.
- •previous cerebral infarction or hemorrhage
Outcomes
Primary Outcomes
Incidence of postoperative overt stroke
Time Frame: 1 year after surgery
Postoperative overt stroke detected by MRI of the brain
Secondary Outcomes
- Physical function after surgery as assessed using Activities of Daily Living (iADL) Scale(1 year after surgery)
- Physical function after surgery as assessed using the Modified Rankin Scale(1 year after surgery)