Determination of glycemic response to the consumption of two specialized formulas for glycemic control
- Conditions
- Hyperglycemia
- Registration Number
- RBR-6zw2fnb
- Lead Sponsor
- Prodiet Medical Nutrition
- Brief Summary
Objective: To assess the glycemic response after ingestion of two specialized oral and enteral nutrition formulas for glycemic control. Methods: Participants were 16 healthy volunteers, aged 21 to 49 years old, with normal glucose tolerance. The volunteers attended the tests fasting for 10 hours, for 5 weeks, and consumed the reference food – glucose solution – for 3 weeks, and the 2 formulas DO and DIG in the following weeks, in amounts equivalent to 25g of available carbohydrates. During the period of 120 minutes, 7 blood samples were taken by capillary blood sampling to determine the glycemic response. The glycemic index (IG) was calculated according to the trapezoidal rule, ignoring areas below the fasting line. The glycemic load (GL) was determined by the formula GL=[(GI (glucose=reference) X “g” of available carbohydrate per serving]/100. Results: The formulas showed low GI and GL, GI=37.8 and GL=6.6 for DO and GI=21.5 and GL=3.5 for DIG. The area under the curve and the GI of the DIG is significantly smaller than that of the DO second t test (p=0.0059). Conclusion: The glycemic response to the products is quite reduced, presenting a curve with a little accentuated shape, without high peak, especially in the modified product.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Healthy volunteers; aged between 18 and 49 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours
Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method