Prevalence of Bacteriuria, Antibiotic Susceptibility, and Treatment Response in Patients With Symptomatic Benign Prostatic Hyperplasia: a Prospective Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Antibiotic therapy
- Conditions
- Bacteriuria in Symptomatic Benign Prostate Hyperplasia
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
- Enrollment
- 131
- Locations
- 1
- Primary Endpoint
- Identification of common pathogens and Antibiotic susceptibility testing
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The goal of this prospective observational study is to identify the common pathogens and antibiotic sensitivity pattern in urine samples of men with symptomatic BPH and to assess severity of LUTS in patients with symptomatic BPH using IPSS score before and after antibiotic therapy.
Detailed Description
This was a hospital-based prospective observational study. All patients with symptomatic BPH attending the Urology Out-Patient Department (OPD) of the study site were enrolled. Informed and written consent was obtained from all participants. Demographic data were recorded, and detailed histories were taken regarding the duration and symptoms of BPH, including incomplete bladder emptying, frequency, intermittency, urgency, weak stream, straining, nocturia, and relevant past history. IPSS scoring was conducted. A thorough clinical examination, including general physical, systemic, and digital rectal examination, was performed. During the rectal examination, the prostate was checked for nodules, softness, induration, or tenderness. Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile.
Investigators
Ishwor Thapaliya
Prinicpal Investigator
Tribhuvan University Teaching Hospital, Institute Of Medicine.
Eligibility Criteria
Inclusion Criteria
- •Patients with symptomatic BPH.
Exclusion Criteria
- •Patients with indwelling catheters
- •Recent antibiotic use
- •Immunocompromised states (e.g., HIV, HCV)
- •Uncontrolled diabetes mellitus (Hemoglobin A1c \> 7%)
- •Steroid therapy
- •Those who declined to provide consent
Arms & Interventions
symptomatic BPH
All patients with symptomatic BPH attending the Urology Out-Patient Department (OPD) of the study site were enrolled. Informed and written consent was obtained from all participants. Demographic data were recorded, and detailed histories were taken regarding the duration and symptoms of BPH and relevant past history. IPSS scoring was conducted. A thorough clinical examination, including general physical, systemic, and digital rectal examination, was performed. During the rectal examination, the prostate was checked for nodules, softness, induration, or tenderness. Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile.
Intervention: Antibiotic therapy
Outcomes
Primary Outcomes
Identification of common pathogens and Antibiotic susceptibility testing
Time Frame: 4 weeks
Urine culture and antibiotic sensitivity tests were conducted to assess the bacteriological profile among symptomatic patients with BPH.
Secondary Outcomes
- Severity of LUTS in patients with symptomatic BPH(4 weeks)