A Comparison Between Child-Pugh and Albumin-Bilirubin Scores

Completed

• Conditions: Rupture, Spontaneous; Hepatocellular Carcinoma; Rupture Liver; Hepatic Impairment
• Interventions: Other: Transcatheter arterial embolization; Procedure: Liver resection

• Registration Number: NCT03534843
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma

Detailed Description

To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma. And to determine which is better in predicting long-term survival and short-term survival.

Study Timeline

• Study Start: 2005-01-01
• Primary Completion: 2015-08-01
• Study Completion: 2018-01-01
• Status Verified: 2018-05
• Study First Submitted: 2018-05-12
• Study First Submitted QC: 2018-05-22
• Study First Posted: 2018-05-23
• Last Update Submitted: 2018-05-24
• Last Update Posted: 2018-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• Be diagnosed as hepatocellular carcinoma pathologically; had a tumor rupture confirmed by Intraperitoneal exploration or clinical signs and symptoms in combination with imaging examination.

Exclusion Criteria

• Be diagnosed as not hepatocellular carcinoma pathologically；had repeated transcatheter arterial chemoembolization(TACE) or a long history (more than 1 year) of cancer treatment; loss of follow up or without complete data.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-surgical treatment	Transcatheter arterial embolization	Patients who received transcatheter arterial embolization (or transcatheter arterial chemoembolization) or conservative treatment
Surgical treatment	Liver resection	Patients who received liver resection or palliative surgery, such as microwave coagulation therapy, hepatic artery ligation, or suturing ligation.

Primary Outcome Measures

Name	Time	Method
Overall survival of all patients	5 years	Overall survival of all patients among different Child-Pugh and albumin-bilirubin scores

Secondary Outcome Measures

Name	Time	Method
Short-term mortality of non-surgical subgroup	Ninety days	Ninety-day mortality of the non-surgical subgroup among different Child-Pugh and albumin-bilirubin scores
Short-term mortality of all patients	Ninety days	Ninety-day mortality of all patients among different Child-Pugh and albumin-bilirubin scores
Short-term mortality of surgical subgroup	Ninety days	Ninety-day mortality of the surgical subgroup among different Child-Pugh and albumin-bilirubin scores