Neohepatic Albumin-Bilirubin Scores on Renal Outcomes in Living-donor Liver Transplantation Recipients

Completed

• Conditions: Acute Kidney Injury; Graft Failure; Chronic Kidney Diseases

• Registration Number: NCT06340607
• Lead Sponsor: Asan Medical Center

Brief Summary

This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.

Detailed Description

Acute kidney injury (AKI) after liver transplantation (LT) significantly affects patient and graft outcomes. The Albumin-Bilirubin (ALBI) score, an objective and sensitive index of liver function, has potential applicability in predicting outcomes following LT. This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.

Study Timeline

• Study Start: 2012-01-05
• Primary Completion: 2020-01-05
• Study Completion: 2022-12-31
• Status Verified: 2024-03
• Study First Submitted: 2024-03-25
• Study First Submitted QC: 2024-03-25
• Last Update Submitted: 2024-03-25
• Study First Posted: 2024-04-01
• Last Update Posted: 2024-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3422

Inclusion Criteria

• living donor liver transplantation recipients (≥18 years)

Exclusion Criteria

• preoperative serum creatinine (sCr) > 1.4 mg/dL, diagnosed CKD or hepatorenal syndrome (HRS), or hemodialysis at baseline

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
acute kidney injury	within 7 days after surgery	determined by change in sCr according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition (increase in sCr of ≥26.5 mmol litre-1 within 48h or ≥1.5 times baseline within 7 days after surgery

Secondary Outcome Measures

Name	Time	Method
chronic kidney injury	within 1 year after surgery	when renal function assessed by calculating estimated serum glomerular filtration using the abbreviated modification of diet in renal disease equation was \<60 mL/min/1.73 m2 for 3 months or more, irrespective of cause
graft failure	the graft failure at overall period (calculated from the date of surgery to the last follow-up) from the date of surgery (up to 10 years)]	graft failure

Trial Locations

Locations (1)

Asan Medical Center; 🇰🇷 Seoul, Song-pa Gu, Korea, Republic of