Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study: Effectiveness of intensive long-term blood pressure lowering treatment, provided by a Triple Pill strategy, for slowing memory decline as measured by Cambridge Neuropsychological Test Automated Battery (CANTAB), in patients with a history of acute stroke due to intracerebral haemorrhage.

Not Applicable

• Conditions: Stroke caused by Intracerebral Haemorrhage (ICH); Hypertension; Cognitive Decline; Dementia; Stroke - Haemorrhagic; Cardiovascular - Hypertension; Neurological - Dementias

• Registration Number: ACTRN12618001677291
• Lead Sponsor: The George Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-10-11
• Study Completion: 2021-02-21
• Last Update Posted: 26 October 2021

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

1.Eligible for, randomised and continuing in the TRIDENT Main Study
2.Must be able to attend the site conducting the cognitive assessments. In Sydney, this will either be at the same site as where TRIDENT study is conducted or at the BMC, University of Sydney, Camperdown.
3.Ability and willingness to undergo neuropsychological testing (i.e. have no major visual, auditory or motor impairments)
4.Language spoken compatible with CANTAB administration (i.e. CANTAB will be administered in the local language(s) of the country in question. E.g. in Australia, the CANTAB will only be administered in English).
5.Provision of written informed consent

Exclusion Criteria

1.Study medication has been permanently stopped prior to or at the 6-month visit of the TRIDENT main study
2.Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) score of 3.3 or higher
3.Cognitive performance indicative of dementia at 6-month TRIDENT main study visit defined by Montreal Cognitive Assessment (MoCA) score less than 24.
4.Evidence of rapid deterioration suggestive of dementia by decline of 3 points in MoCA assessments between randomisation and the 6-month study visits in the TRIDENT main study

Study & Design

• Study Type: Observational
• Study Design: Not specified