Optimised Treatment for Hypertension Trial
- Conditions
- Hypertension
- First Posted Date
- 2025-04-20
- Last Posted Date
- 2025-04-20
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 120
- Registration Number
- NCT06935760
- Locations
- 🇦🇺
The George Institute for Global Health, Sydney, New South Wales, Australia
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
- Conditions
- All-cause MortalityQuality of LifeNeurological DisorderAcute Brain InjuryDisability, IntellectualVentilation, MechanicalIntensive Care Medicine
- Interventions
- Drug: Placebo comparator - no ceftriaxoneDrug: Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- First Posted Date
- 2025-02-11
- Last Posted Date
- 2025-02-11
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 3100
- Registration Number
- NCT06819592
- Locations
- 🇦🇺
Nepean Hospital, Kingswood, New South Wales, Australia
🇦🇺St George Hospital, Kogarah, New South Wales, Australia
🇦🇺Royal North Shore Hospital, Sydney, New South Wales, Australia
The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL
- Conditions
- Intracerebral HemorrhageSpontaneous Intracerebral HemorrhageSupratentorial Intracerebral HaemorrhageAcute Intracerebral HaemorrhageAcute Stroke
- Interventions
- First Posted Date
- 2025-01-08
- Last Posted Date
- 2025-04-10
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 2000
- Registration Number
- NCT06763055
- Locations
- 🇦🇺
Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
🇨🇳West China Hospital of Sichuan University, Chengdu, Sichuan, China
Ultra-early STatin in Patients With Aneurysmal subaRachnoid Hemorrhage (Ue-STAR): a Randomized Controlled Trial
- Conditions
- Subarachnoid HemorrhageSubarachnoid Hemorrhage, AneurysmalAneurysmal Subarachnoid HemorrhageHemorrhage, Aneurysmal Subarachnoid
- Interventions
- First Posted Date
- 2024-08-19
- Last Posted Date
- 2024-08-19
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 522
- Registration Number
- NCT06559072
- Locations
- 🇨🇳
Tianjin Medical University General Hospital, Tianjin, China
FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage
- Conditions
- Aneurysmal Subarachnoid Hemorrhage
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-05-10
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 524
- Registration Number
- NCT06409364
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
- Conditions
- Ischemic Stroke, Acute
- Interventions
- Other: Intensive SBP ControlOther: Moderate SBP ControlOther: Conservative SBP Control
- First Posted Date
- 2024-04-08
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 2000
- Registration Number
- NCT06352619
- Locations
- 🇦🇺
The George Institute for Global Health, Sydney, New South Wales, Australia
🇨🇦University of Calgary, Calgary, Alberta, Canada
ACT-GLOBAL Adaptive Platform Trial for Stroke
- Conditions
- Stroke
- Interventions
- Drug: Standard-dose intravenous tenecteplaseOther: Conservative Blood Pressure ControlOther: PlaceboOther: No deferoxamine mesylate and no colchicineDrug: Low-dose intravenous tenecteplaseOther: Moderate Blood Pressure ControlOther: No intravenous tenecteplaseOther: Intensive Blood Pressure Control
- First Posted Date
- 2024-04-08
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 20000
- Registration Number
- NCT06352632
- Locations
- 🇦🇺
The George Institute for Global Health, Sydney, New South Wales, Australia
🇨🇦University of Calgary, Calgary, Alberta, Canada
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
- Conditions
- Treatment Resistant Depression
- Interventions
- First Posted Date
- 2024-02-26
- Last Posted Date
- 2025-06-03
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 162
- Registration Number
- NCT06278779
- Locations
- 🇦🇺
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
🇦🇺Black Dog Institute, Randwick, New South Wales, Australia
🇦🇺Ramsay Clinic Northside, St Leonards, New South Wales, Australia
The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
- Conditions
- Chronic Kidney Diseases
- Interventions
- First Posted Date
- 2023-09-28
- Last Posted Date
- 2025-06-25
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 1000
- Registration Number
- NCT06058585
- Locations
- 🇦🇺
The Canberra Hospital, Garran, Australian Capital Territory, Australia
🇦🇺Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia
🇦🇺St George Hospital, Kogarah, New South Wales, Australia
Preventing the Rise in Blood Pressure With Age Using Reduced-sodium Salt
- Conditions
- Blood Pressure
- Interventions
- Behavioral: Reduced-sodium potassium-enriched salt
- First Posted Date
- 2023-06-22
- Last Posted Date
- 2024-08-29
- Lead Sponsor
- The George Institute
- Target Recruit Count
- 148
- Registration Number
- NCT05912426
- Locations
- 🇳🇬
Gofidna, Abuja Municipal Area Council, Federal Capital Territory, Nigeria
🇳🇬Jahi-2, Abuja Municipal Area Council, Federal Capital Territory, Nigeria