Improving Negative Symptoms of Psychosis In Real-world Environments

Not Applicable

Completed

Interventions: Behavioral: CBSST-CCT
Behavioral: Goal focused supportive contact

Brief Summary: This study will compare Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training (CBSST-CCT) to a goal-focused supportive contact group to see which intervention better improves symptoms and functioning in people with schizophrenia.

Recruitment & Eligibility

Inclusion Criteria

MUST BE A RESIDENT OF BROADWAY HOME, SAN DIEGO, OR A SERVICE USER OF THE MEETING PLACE, ARETA CROWELL, OR PROJECT ENABLE.

Voluntary informed consent to participate
Age 18 to 65
DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on MINI/SCID
Moderate-to-severe negative symptoms on the Clinical Assessment Interview for Negative Symptoms (CAINS total score >19)
≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed for reading treatment manual)
Stable on medications; no changes within 3 months prior to enrollment

Exclusion Criteria

Prior CBT, SST, or CCT in the past 5 years
Severe positive symptoms on the Positive and Negative Syndrome Scale (PANSS Delusions, Disorganization, Hallucinations, or Suspiciousness >5)
Severe depression on the Calgary Depression Scale for Schizophrenia (CDSS >8)
Ocular damage/disease/surgery/medications that affect pupil dilation
DSM-IV alcohol or substance dependence diagnosis in past 6 months based on the MINI or SCID
Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness) .

Arm && Interventions

Group	Intervention	Description
CBSST-CCT	CBSST-CCT	Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training
Goal-focused supportive contact	Goal focused supportive contact	Goal-focused supportive contact

Primary Outcome Measures

Name	Time	Method
Clinical Assessment Interview for Negative Symptoms (CAINS)	baseline, 12.5 weeks	Change in negative symptom severity at 12.5 weeks. Scores range from 0-52; higher values indicate greater severity.

Secondary Outcome Measures

Name	Time	Method
MATRICS Consensus Cognitive Battery (MCCB)	baseline, 12.5 weeks	Change in cognitive performance in several domains at 12.5 weeks. Scores range from 0-80; higher scores indicate better performance.
UCSD Performance-based Skills Assessment-Brief (UPSA-B)	baseline, 12.5 weeks	Change in communication and financial functioning at 12.5 weeks. Scores range from 0-100; higher scores indicate better performance.
Social Skills Performance Assessment (SSPA)	baseline, 12.5 weeks	Change in social skills performance at 12.5 weeks. Scores range from 2-10; higher scores indicate better social skills.
Specific Levels of Functioning Scale (SLOF)	baseline, 12.5 weeks	Change in self-reported functioning at 12.5 weeks. Scores range from 30-150. Higher score indicates better functioning.
Independent Living Skills Survey (ILSS)	baseline, 12.5 weeks	Change in self-reported functioning at 12.5 weeks. Scores range from 0-1; higher score indicates better skills.
Defeatist Performance Attitudes Scale (DPAS)	baseline, 12.5 weeks	Change in defeatist attitudes at 12.5 weeks. Likert Scale 1-7; scores range from 15-105; higher scores indicate a more severe defeatist performance attitude.
Scale for the Assessment of Negative Symptoms (SANS)	baseline, 12.5 weeks	Change in negative symptom severity at 12.5 weeks. Scores range from 0-25; higher values indicate greater severity.