Impact of Catch-up HPV Vaccination

Terminated

• Conditions: Cervical Cancer; HPV; Vaccine Preventable Disease; Cervical Lesion; HPV Vaccination

• Registration Number: NCT05462249
• Lead Sponsor: University Hospital, Brest

Brief Summary

Each year in France, more than 6000 new cases of HPV inducted cancers are recorded. The vaccinal cover stays insufficient since less than 30% of the french population is vaccinated. Therefore french studies about vaccine efficacy and especially about the catch-up vaccine (done after 15years old) are needed.

HPVAC2 is a prospective, analytic and monocentric study designed to learn the impact of the catch-up HPV vaccination.

Women from 25 years old and born after 1984 may be included if they come to the Brest CHU to do their regular cervical smear. At this time, a survey will be given to know their vaccinal status.

The aim of the study is to prove the efficacy of the catch up vaccination by analyzing the cervical smears results and by comparing the vaccinated group with the not-vaccinated group.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-21
• Primary Completion: 2022-06-30
• Study Completion: 2022-06-30
• Study First Submitted: 2022-07-07
• Study First Submitted QC: 2022-07-13
• Study First Posted: 2022-07-18
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-28
• Last Update Posted: 2025-04-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 354

Inclusion Criteria

• Age limit
• Patient must have done a HPV or smear test during the study period
• Consent necessary

Exclusion Criteria

• Age limit
• No HPV or smear test done in the study period
• Patient not able to give her consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Test HPV and smear test result.	13 months.	Study the effectiveness of anti-HPV vaccine (done between 15 and 19 years old).

Secondary Outcome Measures

Name	Time	Method
Test HPV and smear test result.	13 months.	Compare the effectiveness of anti-HPV vaccine done before and after 15 years old.
Test HPV and smear test result regarding the cervical cancer risk factors.	13 months.	Study the impact of the known cervical cancer risk factors on the smear results.

Trial Locations

Locations (1)

CHU de BREST; 🇫🇷 Brest, Finistère, France