Soutien Des Soins Informels Aux Personnes âgées Fragiles : Accompagnement Des Aidants Sur Base d'Une évaluation Clinique et Biologique de la Charge de Soins.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Levels of biomarkers across groups
研究概览
简要总结
Providing care for a disabled elderly may represent a risk for the health of the caregiver. The objective of the study is to assess the impact of caregiving in terms of clinical and biological markers in relation to disability and cognitive impairment.
详细描述
The investigators hypothesize that an accumulation of stressful events related to care giving may induce a stress response to the caregiver. This stress response can be measured by biological markers (inflammation, transcription and immunity) and also by clinical markers (frailty, physical performance, nutrition). This stress response can be influenced by the subjective burden of the caregiver and by the severity of the disease of the care receiver (Activity of daily life capabilities, cognitive function, behavioral disturbance).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 70 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •living with the care-receiver ( or with a healthy elderly for the controls)
- •care-receiver dependent for at least one Activity of the daily living ( Katz index) or having cognitive disorder ( >2 Global Deterioration Scale)
排除标准
- •institutionalised elderly
- •inability to understand and speak french
- •Acute disease within the past month
- •Anti-inflammatory or immuno-suppressive treatment
- •End-of-life care
结局指标
主要结局
Levels of biomarkers across groups
时间窗: at baseline
biomarkers of inflammation (cortisol, high sensitive C-Reactive Protein,Interleukin-6), immunity (TRECS, telomere length) and transcriptomics/epigenetics
次要结局
- Relation between biomarkers, subjective burden and the care receiver situation(at baseline)
研究者
Professor Maximilien Gourdin
Directeur Médical adjoint aux missions universitaires
Centre Hospitalier Universitaire UCLouvain Namur