The effect of laughing gas on brain elctirc activity and mood
Phase 1
- Conditions
- DepressionThe main aim of this study is to understand how N2O affects - during gas exposure and upon gas withdrawal - slow EEG oscillations in healthy adult volunteers. The aim is to understand the individual variation to the treatments, the dose-response effects of the treatments and the effect of intermittent dosing of the treatments on EEG.Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
- Registration Number
- EUCTR2018-001818-15-FI
- Lead Sponsor
- Tampere University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- 40
Inclusion Criteria
18-40 years, BMI 18-27
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 40
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
no medication/chronic illness, no previous history of psychiatric or substance abuse disorders,
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The main aim of this study is to understand how N2O affects - during gas exposure and upon gas withdrawal - slow EEG oscillations in healthy adult volunteers. ;Secondary Objective: The impact of the treatments on cognitive functions and psychological state ;Primary end point(s): Slow wave oscillations (EEG)<br>;Timepoint(s) of evaluation of this end point: During administration and directly after administration
- Secondary Outcome Measures
Name Time Method Secondary end point(s): Cantab, SCL90 ;Timepoint(s) of evaluation of this end point: Directly after administration