Effects of recreational nitrous oxide use on psychomotor functioning related to driving performance

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Age 18-64
- being in possession of a valid driver's licence (in the Netherlands)
- Being in good physical and mental health as determined by a medical
questionnaire and medical examination by a physician.
- Have experience with the use of nitrous oxide ( >=1 moment in the past with at
least 1x >=2 consecutive doses).
- Experience with the method of administration (100% N2O bolus via balloon
inhalation).
- Be fully vaccinated against sars-cov-2 at least 14 days prior to the first
physical encounter.
- Applicants who are not or incompletely vaccinated for sars-cov-2 can enroll
if they are willing to wear a face mask typ IIR during each visit (with the
exception of during drug administration)

Exclusion Criteria

-use of nitrous oxide > 10 different times in the past year and/or have used
>10 recreational doses (i.e. >10 balloons filled with 3 - 8 liters, 100%
nitrous oxide) per time. These limits describe 80% of recreational users (van
Amsterdam et al., 2015). Adherence to these limits avoids the inclusion of
excessive users whose psychomotor functioning may be impaired by neuropathy
associated with excessive use. - Recent use of sedating, stimulating or
dissociating drugs. This is assessed by questioning and possibly requesting
patient records from GPs. - Recent use of other common intoxicants determined
through a urine test at the start of the training and test days (Surestep*
urine drug screen casette for amphetamines, benzodiazepines, cocaine,
methamphetamines, morphine, THC). - Recent use of alcohol as determined by a
positive breath test. - Excessive use of alcohol (>=21 standard glasses per week
for men or >=14 standard glasses per week for women) - Pregnancy (determined by
Alere* urine hCG test at start of first day of testing) and/or not using any
contraceptives for women of childbearing potential - Latex allergy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Tracking error in mm during divided attention task (DAT)<br /><br>- Reaction times after appearance of target stimuli during divided attention<br /><br>task (DAT) </p><br>

Secondary Outcome Measures