Impact of Encapsulated Fruit, Berry and Vegetable Juice Powder Concentrate on Oxidative Stress, Inflammation and Blood Flow Before and Post Exercise in Overweight, Middle-aged, Women.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Carbonyl groups on protein, oxidized LDL, Malondialdehyde, TNF-alpha, IL-6, Trombelastometry and peripheral microcirculation
研究概览
简要总结
The investigators investigate the impact of an encapsulated fruit, berry and vegetable juice powder concentrate on oxidative stress, inflammation and blood flow before and post exercise in overweight, middle-aged, women.
Main hypotheses (H1):
- The nutraceutical has an impact on oxidative stress reduction.
- The nutraceutical has an impact on inflammation.
- The nutraceutical has an impact on blood flow and microcirculation.
- Walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers.
- Walking exercise for 30 minutes has an impact on blood flow and microcirculation
- The combination of nutraceutical supplementation + walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers, and on blood flow/microcirculation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 35 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI > 27
- •praemenopausal
- •non smokers
- •eligibility for exercise
- •4wk wash out
排除标准
- •all people not matching this age group
- •BMI > 40 and < 27
- •peri- or postmenopausal women
- •all women taking dietary supplements
- •all women that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure > 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..)
- •Diabetics
- •osteoporosis or osteopenia
结局指标
主要结局
Carbonyl groups on protein, oxidized LDL, Malondialdehyde, TNF-alpha, IL-6, Trombelastometry and peripheral microcirculation
时间窗: 6 months
Carbonyl groups on protein as indicators of protein oxidation; oxidized LDL, Malondialdehyde as indicators of Lipidoxidation; TNF-alpha, IL-6 as indicators of inflammation; Trombelastometry: clotting time, thrombocyte ahesion, trombocyte aggregation from whole blood as indicators for blood flow and hemostasis; Peripheral microcirculation in subcutis as indicator for blood flow in peripheral subcutis.
次要结局
未报告次要终点
研究者
Lamprecht Manfred PhD, PhD
Principal investigator
Green Beat