Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by EIT in Patients With ARDS

Recruiting

• Conditions: Critical Illness

• Registration Number: NCT05873647
• Lead Sponsor: Wuhan Union Hospital, China

Brief Summary

Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO reactivity and the physiological mechanism underlying changes in oxygenation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-05
• Study Start: 2023-05-01
• Study First Submitted: 2023-05-10
• Study First Submitted QC: 2023-05-15
• Last Update Submitted: 2023-05-15
• Study First Posted: 2023-05-24
• Last Update Posted: 2023-05-24
• Primary Completion: 2025-05-01
• Study Completion: 2025-05-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients aged ≥ 18 years;
2. Patients are intubated and mechanically ventilated.

Exclusion Criteria

1. EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc;
2. With a history of cerebral hemorrhage in the past half year, as well as bleeding in any site of the body;
3. Pneumothorax;
4. Medium or massive pleural effusion;
5. Refractory shock;
6. Pregnant
7. With chronic kidney disease
8. Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output;
9. Failure to sign informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lung ventilation/perfusion ration	3 hours	Lung ventilation/perfusion ration after iNO assessed by EIT

Secondary Outcome Measures

Name	Time	Method
Shunting	30minutes and 3 hours	Lung shunting% after iNO assessed by EIT
Lung perfusion distribution	30minutes and 3 hours	Lung ventilation/perfusion ration after iNO assessed by EIT
Dead space	30minutes and 3 hours	Lung dead space after iNO assessed by EIT
Right ventricular function	30minutes and 3 hours	Right ventricular function assessed by echocardiography
Oxygenation index	30minutes and 3 hours	Oxygenation index= arterial partial pressure of oxygen/fraction of inspired oxygen
Static respiratory compliance (Crs)	30minutes and 3 hours	Crs=tidal volume/driving pressure
Arterial partial pressure of carbon dioxide (PaCO2)	30minutes and 3 hours	PaCO2 is one of the key indicators of pulmonary ventilation which can be obtained from arterial blood gas analysis.
Cardiac output	30minutes and 3 hours	Cardiac output assessed by echocardiography

Trial Locations

Locations (1)

Hongling Zhang; 🇨🇳 Wuhan, Hubei, China