Topical ciclosporin A eye drops for graft rejectio

Completed

• Conditions: Corneal graft rejection; Injury, Occupational Diseases, Poisoning; Failure and rejection of transplanted organs and tissues

• Registration Number: ISRCTN52781697
• Lead Sponsor: Indian Council of Medical Research (ICMR) (India)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-09-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

1. Patients greater than or equal to 9 years of age, either sex
2. Eyes undergoing penetrating keratoplasty
3. With two or more quadrants of corneal vascularisation extending at least 2 mm into the cornea
4. Cases of corneal re-grafts

Exclusion Criteria

1. Grafts that are not high-risk
2. Pregnant/lactating females
3. Children below 9 years of age
4. Patients who refused to give consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
incidence of occurrence of corneal endothelial graft rejection after high-risk keratoplasty in the study and control group at the end of one year.

Secondary Outcome Measures

Name	Time	Method
1. Incidence of reversal of graft rejection in the study and control group at the end of one year<br>2. Incidence of occurrence possible side effects of using ciclosporin A eye drops in the study group at the end of one year