The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

Completed

• Conditions: Behçet's Disease
• Interventions: Other: serum levels of angiogenin, bFGF, VEGF

• Registration Number: NCT01720628
• Lead Sponsor: Turkish Ophthalmology Society

Brief Summary

Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.

Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Primary Completion: 2011-11
• Study Completion: 2012-02
• Status Verified: 2012-10
• Study First Submitted: 2012-10-23
• Study First Submitted QC: 2012-10-31
• Last Update Submitted: 2012-10-31
• Study First Posted: 2012-11-02
• Last Update Posted: 2012-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 86

Inclusion Criteria

• age between 18-65
• fulfilling the international diagnostic criteria for Behçet's disease

Exclusion Criteria

• to have another systemic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Behçet's patients	serum levels of angiogenin, bFGF, VEGF	Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group

Primary Outcome Measures

Name	Time	Method
Serum levels of angiogenin in Behçet's patients with or without ocular involvement	1 year	The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance.

Secondary Outcome Measures

Name	Time	Method
Serum levels of bFGF in Behçet's patients with or without ocular involvement	1 year

Trial Locations

Locations (1)

Ankara University, Faculty of Medicine, Department of Ophthalmology; 🇹🇷 Ankara, Turkey