Possible Association between Behcet Disease and Periodontal Diseases

Completed

• Conditions: Behcet diseasePeriodontal diseasePeriodontitisGingivitis; Behcet disease; Gingivitis; Periodontitis; Interleukin; Tumor necrosis factor; Nitric Oxide

• Registration Number: TCTR20240722003
• Lead Sponsor: Gazi University

Brief Summary

Mean salivary IL-1beta, TNF-alpha levels were elevated , and mean NO level was decreased in BD patients with gingivitis compared to patients without BD. In contrast, mean NO level in crevicular fluid was higher in Behcet's patients with periodontitis than in patients without BD. Furthermore, among Behcet's patients, those with vascular involvement had lower salivary NO level compared to patients without vascular involvement

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-08-01
• Results First Posted: 2022-09-01
• Study Start: 2024-07-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

Periodontitis was diagnosed with a severity of Stage II, pocket depth 3 mm and Stage III, pocket depth 5 mm, a generalized pattern according to the criteria by the criteria 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Gingivitis was diagnosed as according to a BOP score 10%, without attachment loss and radiographic bone loss.Patients were diagnosed according to the International Criteria for Behcet Disease (ICBD). ICBD is based on ocular lesions, genital ulcers, oral aphthous ulcers, skin manifestations, vascular involvement and positive pathergy test. Systemic involvement associated with BD, current symptoms and the use of any systemic medications were recorded.

Exclusion Criteria

Stage IV periodontitis
autoimmune diseases
pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified