Loss of Y Chromosome in Aortic Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Loss of Y chromosome
研究概览
简要总结
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aortic stenosis (valve area <1.5cm2)
排除标准
- •Bicuspid aortic valve
- •History of radiation to chest
- •Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis
- •Active cancer
结局指标
主要结局
Loss of Y chromosome
时间窗: 1 day
This is a cross-sectional case-control study where the outcome measure is the percentage of circulating cells that have loss-of-Y chromosome
次要结局
未报告次要终点
研究者
Jonathan Lindner, MD
Professor of Medicine
University of Virginia