Evaluation of bile-acid concentration in cerebrospinal fluid

• Conditions: Hyperbilirubinemia; R17.9; Hyperbilirubinaemia without mention of jaundice, not elsewhere classified

• Registration Number: DRKS00017291
• Lead Sponsor: niversitätsmedizin GöttingenKlinik für Anästhesiologie

Brief Summary

At a median time of 19.75 h after a cerebral insult, the concentration of bile acids in the CSF was minute and almost negligible. The CSF concentrations of total bile acids (TBAs) were significantly lower compared to the serum concentrations (serum 0.37 µmol/L [0.24, 0.89] vs. 0.14 µmol/L [0.05, 0.43]; p = 0.033). The ratio of serum-to-CSF bile acid levels calculated from the respective total concentrations were 3.10 [0.94, 14.64] for total bile acids, 3.05 for taurocholic acid, 14.30 [1.11, 27.13] for glycocholic acid, 0.0 for chenodeoxycholic acid, 2.19 for taurochenodeoxycholic acid, 1.91 [0.68, 8.64] for glycochenodeoxycholic acid and 0.77 [0.0, 13.79] for deoxycholic acid; other bile acids were not detected in the CSF. The ratio of CSF-to-serum S100 concentration was 0.01 [0.0, 0.02]. Serum total and conjugated (but not unconjugated) bilirubin levels and serum TBA levels were significantly correlated (total bilirubin p = 0.031 [0.023, 0.579]; conjugated bilirubin p = 0.001 [0.193, 0.683]; unconjugated p = 0.387 [-0.181, 0.426]). No correlations were found between bile acid concentrations and age, delirium, intraventricular blood volume, or outcome measured on a modified Rankin scale.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-15
• Study Completion: 2023-03-22
• Results First Posted: 2023-11-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Women and men
• Age> 18 years
• Patients in the operative intensive care unit of the Department of Anaesthesiology (0119)
• External ventricular drainage or lumbar drainage

Exclusion Criteria

No informed consent

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concentration of Bile Acids in cerebrospinal fluid

Secondary Outcome Measures

Name	Time	Method
Difference in concentration between serum and cerebrospinal fluid