Evaluation of cerebral circulation and metabolic properties in patients undergoing normothermic cardiopulmonary bypass with acute normovolemic hemodilution.
- Conditions
- cardiopulmonary bypass, hemodiltion, cerebral autoregulation, micro embolic signals.
- Registration Number
- NL-OMON28354
- Lead Sponsor
- Jos Maessen, MD, PhDMaastricht University Medical Center, Dept. CTCPhone: +31-43-3877070
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Elective adult candidates for CABG surgery using CPB;
2. Male gender;
Exclusion Criteria
1. Patients suffering from neurological disorders (e.g. cerebrovascular accident);
2. Patients suffering from renal diseases (e.g. renal failure, defined as laboratory tests indicating values of 2 or more times the normal values [urea >= 50 U/L, kreatinine >= 170 micromol/L]);
Study & Design
- Study Type
- Not specified
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effects of normovolemic hemodilution levels during CPB on the dynamic cerebral autoregulation and cerebrovascular reactivity.
- Secondary Outcome Measures
Name Time Method 1. To evaluate the dynamic cerebral autoregulation with transcranial Doppler velocity and near infrared spectroscopy at different PaCO2 levels during normothermic CPB;<br /><br><br>2. To evaluate the relation between PaCO2 values and the amount of micro emboli signals during CPB.