Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Completed

• Conditions: Disorders of Consciousness; Transient Ischemic Attack
• Interventions: Other: No intervention

• Registration Number: NCT06403176
• Lead Sponsor: First Affiliated Hospital of Zhejiang University

Brief Summary

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Detailed Description

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions

Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.

Study Timeline

• Status Verified: 2022-03
• Study First Submitted: 2022-03-14
• Study Start: 2022-05-01
• Primary Completion: 2024-03-30
• Study Completion: 2024-04-30
• Study First Submitted QC: 2024-05-06
• Last Update Submitted: 2024-05-06
• Study First Posted: 2024-05-07
• Last Update Posted: 2024-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.Patients with consciousness disorder caused by various severe brain injuries

Exclusion Criteria

1. Patients who have been judged brain dead
2. There are persistent epileptic activity, inhibition or seizure inhibition patterns
3. Recent fever, abnormal liver and kidney function
4. Previous history of neurological or mental illness
5. Have a history of tumor
6. Inflammatory bowel diseases, hyperlipidemia, gastritis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Minimally conscious state (MCS)	No intervention	Minimally conscious state (MCS): have reproducible signs of awareness and exhibit fluctuations in consciousness
Vegetative state (VS)	No intervention	Vegetative state (VS): can open their eyes and preserve sleep-wake cycles, but unaware of themselves and their surroundings
Patients with In-Stent Restenosis	No intervention	In-Stent Restenosis was defined as greater than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).
Patients with Non-Restenosis	No intervention	In-Stent Restenosis was defined as less than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).

Primary Outcome Measures

Name	Time	Method
Patient clinical outcome	12 months	The patients were followed up for 12 months after blood collection to observe the clinical outcome

Trial Locations

Locations (1)

The First Affiliated Hospital of Zhejiang University; 🇨🇳 Hanzhou, Zhejiang, China