To study the impact of decrease blood supply and oxygen supply to the brain in patients of sepsis, also to compare two different modalities (NIRS and Transcranial Doppler)to correlate the readings of these modalities weather they show the same trends.
Not Applicable
- Conditions
- Health Condition 1: R652- Severe sepsis
- Registration Number
- CTRI/2023/02/049920
- Lead Sponsor
- nil
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients with septic encephalopathy admitted in intensive care unit.
age more than 18 years either gender.
Exclusion Criteria
Patient refuse to consent.
Patient those are not a documented case of sepsis.
Patient who cannot communicate.
Patient having history of neurological illness.
Patient having any history of neurological trauma.
Patient having any history of Psychiatric illness.
Patients having cerebrovascular disease.
Patient with alcohol dependance.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We are expecting a positive co-relation between indices observed by transcranial doppler for altered cerebral blood flow and rScO2 for regional cerebral tissue oxygenation in patient with sepsis induced encephalopathy.Timepoint: We are expecting a positive co-relation in data observed by two different modality i.e. transcranial doppler for altered cerebral blood flow and rScO2 for regional cerebral tissue oxygenation in patient with sepsis induced encephalopathy at baseline, day1,day2,day3,day4 and day 5.
- Secondary Outcome Measures
Name Time Method overall impact of altered blood flow and oxygenation to the brain in terms of altered mental status i. e. decline in baseline GCS, ICU CAM score and MMSE.Timepoint: Assessment of alterations in mental status changes with respect to changes in cerebral tissue oxygenation and cerebral blood flow in Patient of septic encephalopathy with help of GCS, MMSE, ICUCAM score at baseline and day 5.