Omega-3 Dietary Supplementation, Immune Function, and Mood
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 138
- 试验地点
- 2
- 主要终点
- Serum ln(TNF-a)
研究概览
简要总结
This study is designed to examine the effects of fish oil on immune function and mood.
详细描述
The beneficial effects of fish oil (or eating fish more frequently) include reductions in triglycerides, blood pressure, and heart rate, as well as increases in HDL cholesterol, the "good" type of cholesterol. In addition, certain aspects of immune function also appear to show favorable responses to fish oil supplementation, and some studies suggest that fish oil helps to improve mood and decrease depression.
This study is designed to examine how supplementation with omega-3 polyunsaturated fatty acids (key fish oil components) affects aspects of your immune response, and your mood; because some research suggests that people who eat more fish may do better during stressful times, the study will also examine how fish oil affects your immune response to stress, certain stress hormone responses, and your psychological response to stress.
For detailed information about the study, please visit our website at http://www.stressandhealth.org
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 88 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •NOT currently taking any sort of fish oil or omega 3 supplement
排除标准
- •Use of blood pressure medicines, cholesterol-lowering drugs, steroids, or antidepressants
- •Certain lifestyle habits such as smoking or exercising vigorously for 2 or more hours a week may also exclude applicants from participating
结局指标
主要结局
Serum ln(TNF-a)
时间窗: Baseline & 4 months
log-transformed serum Tumor Necrosis Factor-alpha (TNF-alpha)
Serum ln(IL-6)
时间窗: Baseline & 4 months
log-transformed serum Interleukin-6 (IL-6)
ln(CES-D)
时间窗: Baseline & 4 months
log-transformed Center for Epidemiologic Studies Depression Scale (CES-D) score The CES-D is a self-report scale designed to measure current symptoms of depression rated on a four-point likert scale. Scores range from 0-60, with higher scores indicating a higher frequency of depressive symptoms.
次要结局
未报告次要终点
研究者
Janice Kiecolt-Glaser
Professor of Psychiatry and Psychology
Ohio State University