Correlation Between qNOX and Analgesia Nociception Index (ANI) Values During General Anesthesia

Completed

• Conditions: Analgesia

• Registration Number: NCT06351072
• Lead Sponsor: University of Padova

Brief Summary

qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia.

No trials have compared them, so with this trial authors want to explore the correlations between them.

Detailed Description

qNOX and ANI are two indexes evaluting the anaglesia conduction during general anesthesia.

Even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qNOX is derived by the electroencephalogrm (EEG), the ANI is derived by heart rate variation.

No trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.

Study Timeline

• Study First Submitted: 2024-03-25
• Study First Submitted QC: 2024-03-29
• Study Start: 2024-04-02
• Study First Posted: 2024-04-08
• Primary Completion: 2024-09-01
• Status Verified: 2024-10
• Study Completion: 2024-10-01
• Last Update Submitted: 2024-10-21
• Last Update Posted: 2024-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and remifentanil (Eleveld model)

Exclusion Criteria

• Neurological disease
• Psychiatric disease
• Obesity
• Regional anesthesia performed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between qNOX and ANI values	qNOX, ANI, pupoillometry values, propofol and remifentanil concentration during induction, intubation, after post-tetanic count at the trend-of-four and maintenance phase of general anesthesia detected with target controlled inusion will be paired.	qNOX and ANI values will be compared to check the correspondance in evaluting analgesia level

Secondary Outcome Measures

Name	Time	Method
Correlation between qNOX from CONOX and analgesia nocicpetion index (ANI) values and postoperative delirium	qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative delirium, evaluated with CAM and 4AT score after 24 hours	Evaluate if qNOX or ANI values relate to postoperative delirium
Correlation between qNOX from CONOX and Analgesia nocicpetion index (ANI) values and postoperative pain	qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative pain, evalued with NRS score after 24 hours	Evaluate if qNOX or ANI values relate to postoperative pain

Trial Locations

Locations (1)

Treviso Regional Hospital; 🇮🇹 Treviso, TV, Italy