Correlation Between qNOX Values of the CONOX Monitor and Analgesia Nociception Index (ANI) Values During General Anesthesia Conducted With Propofol and Remifentanil TCI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Analgesia
- Sponsor
- University of Padova
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Correlation between qNOX and ANI values
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
qNOX and ANI are two indexes evaluting the analgesia conduction during general anesthesia.
No trials have compared them, so with this trial authors want to explore the correlations between them.
Detailed Description
qNOX and ANI are two indexes evaluting the anaglesia conduction during general anesthesia. Even if the aim is the same (to measure the nociception level) these indexes utilize different algorithm: the qNOX is derived by the electroencephalogrm (EEG), the ANI is derived by heart rate variation. No trials have compared them, so with this trial authors want to explore the correlations between them, and if altered values of one of them is stronger related to postoperative pain and delirium.
Investigators
Federico Linassi
MD, principal invesigator
University of Padova
Eligibility Criteria
Inclusion Criteria
- •Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and remifentanil (Eleveld model)
Exclusion Criteria
- •Neurological disease
- •Psychiatric disease
- •Regional anesthesia performed
Outcomes
Primary Outcomes
Correlation between qNOX and ANI values
Time Frame: qNOX, ANI, pupoillometry values, propofol and remifentanil concentration during induction, intubation, after post-tetanic count at the trend-of-four and maintenance phase of general anesthesia detected with target controlled inusion will be paired.
qNOX and ANI values will be compared to check the correspondance in evaluting analgesia level
Secondary Outcomes
- Correlation between qNOX from CONOX and analgesia nocicpetion index (ANI) values and postoperative delirium(qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative delirium, evaluated with CAM and 4AT score after 24 hours)
- Correlation between qNOX from CONOX and Analgesia nocicpetion index (ANI) values and postoperative pain(qNOX, ANI and remifentanil concentrations recorded during induction, intubation and maintenance phase of general anesthesia will be related to postoperative pain, evalued with NRS score after 24 hours)