Carotenoids in the Skin and Immune Aging

Recruiting

• Conditions: No Condition; Skin Carotenoids and Immune-aging

• Registration Number: NCT07221643
• Lead Sponsor: Stanford University

Brief Summary

This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-09-30
• Status Verified: 2025-10
• Study Start: 2025-10-09
• Study First Submitted QC: 2025-10-23
• Last Update Submitted: 2025-10-23
• Study First Posted: 2025-10-28
• Last Update Posted: 2025-10-28
• Primary Completion: 2026-01-01
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Willing and able to provide written informed consent
• Age 18-30 years OR 65 years and older
• Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
• Fiitzpatrick I-VI (all skin types)

Exclusion Criteria

• Pregnant or breastfeeding
• uncontrolled medical conditions
• Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
• Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
• Unable to follow study protocol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Skin carotenoid levels and skin aging features	one day	We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.

Secondary Outcome Measures

Name	Time	Method
Skin carotenoid levels and biomarkers of aging	one day	We will assess the skin carotenoid levels' correlation with biomarkers associated with aging, such as C-reactive protein, telomere length, telomerase activity etc.
Skin carotenoid levels and self-reported perception of health	2 weeks	We will assess the skin carotenoid levels' correlation with self reported scores on general health and health beliefs, incidence of respiratory, gut and skin allergy symptoms, and sleep quality.

Trial Locations

Locations (1)

Stanford Health - General Dermatology Clinic; 🇺🇸 Redwood City, California, United States