Sublingual Microcirculatory Flow Measurements During Haemodialysis in Relation to Blood Volume Change
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Difference between sublingual microvascular flow index between 2 types of ultrafiltration
研究概览
简要总结
- SDF is validated by measuring changes in microcirculation in sepsis patients with MOF (Boerma studies).
- SDF is validated by measuring changes in microcirculation in stable chronic hemodialysis patients (NDT 2009 Bemelmans).
- Ultrafiltration in stable chronic hemodialysis leads to a decrease in sublingual microcirculatory flow (NDT 2009 Bemelmans).
- Trendelenburg position improves the sublingual microcirculatory flow at the end of hemodialysis treatment (NDT 2009 Bemelmans).
- Hemodialysis with ultrafiltration leads to a significant reduction of myocardial perfusion and cardiac output (NDT 2009 Dasselaar)
- Cardiac output measurement during dialysis is not practical.
- BVM is a validated method for hypotension due to ultrafiltration to prevent the amount of ultrafiltration online change based on the measured haemoconcentration (ref Dasselaar et al NDT 2005).
- BCM is a validated measurement to the dry weight in hemodialysis patients measured by a bioimpedance technique (NDT Passauer et al 2009).
详细描述
The search for an optimal method of ultrafiltration with minimal hypoperfusion of vital organs.
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Stabile hemodialysis patients with dialysis dependancy for more than 3 months, with adequate access
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Study duration 3 weeks
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Number of hemodialysis treatment for purposes of study: 3
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Timing hemodialysis treatments for Study session Monday or Tuesday after the weekend (randomized design in the sessions)
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session a: 5 hours total duration: 4 hours HD without UF followed by 1 hour GUF
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Session b: 4 hours total duration: 4 hours HD with UF
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session c: 4 hours total duration: 4 hours HD with UF and BVM
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UF is determined by actual target weight.
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Measurements during sessions:
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In each session in advance: blood pressure, pulse, weight, BCM, laboratory tests (Hb, Hct, Na, K, urea, creatinine, calcium, albumin, phosphate, nt-proBNP, troponin T, CRP)
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During each session at t = 0, t = 1 hour, t =2 hours and t = 4 hours: SDF, blood pressure, pulse, UF at that time, UF rate at that time
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End each session: blood pressure, pulse, weight, BCM, laboratory tests (Hb, Hct, Na, K, urea, creatinine, calcium, albumin, phosphate, nt-proBNP, troponin T, CRP)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •dialysis patient
- •age > 18
- •informed consent
排除标准
- •no adequate access
- •instable hemodynamics
结局指标
主要结局
Difference between sublingual microvascular flow index between 2 types of ultrafiltration
时间窗: 3 weeks
次要结局
未报告次要终点
研究者
E.C. Boerma
Dr
Medical Centre Leeuwarden