Evaluation of Sublingual Microcirculation in Burn During Resuscitation

• Conditions: Burn Shock

• Registration Number: NCT05096559
• Lead Sponsor: Cairo University

Brief Summary

The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation.

Microcirculation camera will be placed on the base of the tongue and at different four quadrants. • Microcirculation parameters at baseline and after 8h , 16h and 24h of fluid resuscitation will be recorded. Fluid resuscitation with lactated ringer according to Parkland formula (4 ml/kg/%TBSA) 50% given during the first 8 hours, with the remainder given during the following 16 hours, will be initiated to maintain a urinary output of 0.5ml/kg/hr.Norepinephrine infusion will be started in case of circulatory failure at a rate of 0.02mic/kg/min to maintain MAP of 65-70mmHg.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-01
• Status Verified: 2021-10
• Study First Submitted: 2021-10-15
• Study First Submitted QC: 2021-10-15
• Last Update Submitted: 2021-10-15
• Study First Posted: 2021-10-27
• Last Update Posted: 2021-10-27
• Primary Completion: 2022-02-01
• Study Completion: 2022-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age more than 18 years old
• Burn >20% TBSA
• Patients with burn admitted within the 1st 6 hours

Exclusion Criteria

• Age < 18 years old.
• Pregnant patients.
• Patients with severe renal insufficiency.
• Patients shocked due to other causes as sepsis, hypovolaemia or cardiogenic shock
• Patients with airway edema that preclude the measurement of sublingual microcirculation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• Lactate level	24 hours	mmol/L

Secondary Outcome Measures

Name	Time	Method
total vessel density	24 hours	mm/mm2

Trial Locations

Locations (1)

Kasr Al Ainy hospitals; 🇪🇬 Cairo, Egypt