The Evaluation of Sublingual Microcirculation To Guide Fluid Resuscitation In Patients With Burn: Prospective Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Burn Shock
- Sponsor
- Cairo University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- • Lactate level
- Last Updated
- 4 years ago
Overview
Brief Summary
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation.
Microcirculation camera will be placed on the base of the tongue and at different four quadrants. • Microcirculation parameters at baseline and after 8h , 16h and 24h of fluid resuscitation will be recorded. Fluid resuscitation with lactated ringer according to Parkland formula (4 ml/kg/%TBSA) 50% given during the first 8 hours, with the remainder given during the following 16 hours, will be initiated to maintain a urinary output of 0.5ml/kg/hr.Norepinephrine infusion will be started in case of circulatory failure at a rate of 0.02mic/kg/min to maintain MAP of 65-70mmHg.
Investigators
Shymaa Fathy
Lecturer of anesthesia and SICU
Cairo University
Eligibility Criteria
Inclusion Criteria
- •Age more than 18 years old
- •Burn \>20% TBSA
- •Patients with burn admitted within the 1st 6 hours
Exclusion Criteria
- •Age \< 18 years old.
- •Pregnant patients.
- •Patients with severe renal insufficiency.
- •Patients shocked due to other causes as sepsis, hypovolaemia or cardiogenic shock
- •Patients with airway edema that preclude the measurement of sublingual microcirculation
Outcomes
Primary Outcomes
• Lactate level
Time Frame: 24 hours
mmol/L
Secondary Outcomes
- total vessel density(24 hours)