Exploring the Benefits of Eccentric Training for Aging Adults With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Stair-stepping smoothness
研究概览
简要总结
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Osteoarthritis (OA) Group:
- •Aged 40-70 years
- •Radiographically confirmed knee OA (Kellgren-Lawrence [KL] Grade 2 or 3)
- •Able to walk independently (assistive devices permitted)
- •Inclusion Criteria Healthy Control Group:
- •Aged 40-70 years
- •No radiographic evidence of knee OA (KL Grade 0 or 1)
- •No frequent knee pain
- •No history of:
- •Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)
- •Significant knee injury (e.g., ligament tears, fractures, dislocations)
- •Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)
排除标准
- •Uncontrolled hypertension or other cardiovascular disease
- •A musculoskeletal condition preventing physical testing
- •Neurological muscle weakness (e.g., stroke, spinal cord injury)
- •BMI >34.9 kg/m²
- •Recent hospitalization (past 3 months)
研究组 & 干预措施
Initial-Exercise'
The initial exercise group will participate in an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week. Participants will then cease the intervention for 8 weeks to enter a detraining period.
干预措施: Eccentric resistance training (Other)
Delayed-Exercise
The 'Delayed-Exercise' group will maintain their normal activity, without intervention, for the first 8 weeks of the study. In the second half of the study, they will begin the same 8-week kBox training completed by the 'Initial-Exercise' group.
干预措施: Eccentric resistance training (Other)
结局指标
主要结局
Stair-stepping smoothness
时间窗: Baseline, up to 10 weeks, up to 19 weeks
Stair-stepping smoothness quantifies motor coordination during the step-up-and-over test by analyzing the fluidity and consistency of limb movements while ascending and descending stairs. It is calculated using a jerk-based smoothness metric adapted from Gonzales et al., where jerk is defined as the third derivative of the position trajectory with respect to time. The smoothness index is derived by numerically differentiating the position data x(t) obtained from motion capture three times to calculate jerk, then squaring and summing these jerk values over the duration of the movement. Lower values of the smoothness index indicate smoother, more coordinated movements. Differences in this metric will be compared between knee osteoarthritis patients and age-matched healthy controls, with variance explained through linear regression models, and between exercise intervention and delayed exercise subgroups to assess changes in motor control during stair negotiation. Unitless.
次要结局
- Stepping smoothness symmetry index(Baseline, up to 10 weeks, up to 19 weeks)
- Muscle echogenicity(Baseline, up to 10 weeks, up to 19 weeks)
- Muscle thickness(Baseline, up to 10 weeks, up to 19 weeks)
- Muscle texture analysis (gray-level co-occurrence matrix)(Baseline, up to 10 weeks, up to 19 weeks)
- Grip strength(Baseline, up to 10 weeks, up to 19 weeks)
- Lower limb strength(Baseline, up to 10 weeks, up to 19 weeks)
- Timed stair ambulation(Baseline, up to 10 weeks, up to 19 weeks)
- Short Physical Performance Battery (SPPB)(Baseline, up to 10 weeks, up to 19 weeks)
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Position(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Linear Velocity(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Linear Acceleration(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Angular Velocity(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Angular Acceleration(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Range of Motion(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Forces(Baseline, up to 10 weeks, up to 19 weeks)
- Joint Moments (Torques)(Baseline, up to 10 weeks, up to 19 weeks)
- Self-reported pain(Baseline, up to 10 weeks, up to 19 weeks)