The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork

Not Applicable

Completed

• Conditions: Open-angle Glaucoma
• Interventions: Procedure: trabeculectomy

• Registration Number: NCT02638181
• Lead Sponsor: Lv Yingjuan

Brief Summary

This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Study First Submitted: 2015-12-14
• Study First Submitted QC: 2015-12-17
• Study First Posted: 2015-12-23
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-08
• Last Update Posted: 2017-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• intraocular pressure greater than 22 mmHg with two or more medications
• wide anterior chamber angle
• glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect
• visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion Criteria

• the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
trabeculectomy	trabeculectomy	-

Primary Outcome Measures

Name	Time	Method
the expressions of matrix metalloproteinase 13 and calcium-sensing receptor	one hour after operation

Secondary Outcome Measures

Name	Time	Method
histological changes of trabecular meshwork	one hour after operation

Trial Locations

Locations (1)

Tianjin Medical University Eye Hospital; 🇨🇳 Tianjin, Tianjin, China