The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork
Not Applicable
Completed
- Conditions
- Open-angle Glaucoma
- Registration Number
- NCT02638181
- Lead Sponsor
- Lv Yingjuan
- Brief Summary
This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- intraocular pressure greater than 22 mmHg with two or more medications
- wide anterior chamber angle
- glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect
- visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
Exclusion Criteria
- the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method the expressions of matrix metalloproteinase 13 and calcium-sensing receptor one hour after operation
- Secondary Outcome Measures
Name Time Method histological changes of trabecular meshwork one hour after operation
Trial Locations
- Locations (1)
Tianjin Medical University Eye Hospital
🇨🇳Tianjin, Tianjin, China
Tianjin Medical University Eye Hospital🇨🇳Tianjin, Tianjin, China