NCT02638181已完成不适用
The Expression of Matrix Metalloproteinase 13（MMP13）, Tissue Inhibitor of Metalloproteinases 3（TIMP13）, and Calcium-sensing Receptor（CaSR） in Human Trabecular Meshwork
Lv Yingjuan1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2013年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- the expressions of matrix metalloproteinase 13 and calcium-sensing receptor
研究概览
简要总结
This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •intraocular pressure greater than 22 mmHg with two or more medications
- •wide anterior chamber angle
- •glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect
- •visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
排除标准
- •the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc
结局指标
主要结局
the expressions of matrix metalloproteinase 13 and calcium-sensing receptor
时间窗: one hour after operation
次要结局
- histological changes of trabecular meshwork(one hour after operation)
研究者
Lv Yingjuan
department of ophthamology
Tianjin Medical University Eye Hospital
研究点 (1)
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