Case-control Study on Matrix Metalloproteinase Levels in Tissue in Patients With Keloid Scar
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Correlate the level of matrix metalloproteinases in keloid tissue versus normal skin
研究概览
简要总结
Purpose:
To compare the levels of matrix metalloproteinase-1 (MMP-1), MMP-8, MMP-13 and tissue inhibitor of metalloproteinases (TIMPs) in keloid skin tissue with normal skin in the same patient and with normal discarded skin tissue (control). The investigators aim to correlate between levels of MMPs in patients with keloid scarring in comparison with normal and discarded tissue.
详细描述
The investigators anticipate enrolling 20 patients into our study. The COST of the excision and related procedures WILL NOT be covered by the research study. Patient and patient's health insurance provider will be responsible for all costs of treatment and related procedures.
- Patients must be at least 18 years old and have a keloid which they will agree to have biopsied.
- During a screening visit we will obtain determine if patient fulfills inclusion/exclusion criteria, obtain informed visit and HIPAA authorization. Demographic information and pertinent medical history will be obtained and risk factors will be explained to the patient.
- A focused dermatological exam will be performed assessing the severity and location of the keloid as well as skin phototype of the patient.
- A Henry Ford Hospital Dermatosurgeon will excise a biopsy of the keloid tissue and normal tissue from enrolled patients and the specimens will be sent to the lab for workup. Discarded skin samples will also be collected from Henry Ford Plastic Surgery and Dermatology department and analyzed as an additional control for normal skin. The discarded skin samples (controls) will be region specific and matched with a keloid sample that is from the same area of the body as the biopsy sample.
- Levels of MMP's will be measured in keloid, normal tissue samples and discarded skin samples.
- Levels of TIMPs will be measured in keloid, normal tissue and discarded tissue samples
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For inclusion, the subject must:
- •Be at least 18 years old;
- •Have a keloid and accept to have it excised;
- •Be able to understand the requirements for the study, the risks involved and are able to sign the informed consent form;
- •Agree to follow and undergo all study-related procedures
排除标准
- •Subjects will be excluded if any of the following apply:
- •Women who are lactating, pregnant, or planning to become pregnant;
- •Patients with a recent history of serious systemic disease;
- •Patients who are receiving treatment for the keloid or have received treatment in the past 1 year.
- •Any reason the investigator feels the patient should not participate in the study.
结局指标
主要结局
Correlate the level of matrix metalloproteinases in keloid tissue versus normal skin
时间窗: One time office visit for keloid excision, there will be no follow up visits for patient. Keloid tissue will be analyzed in Henry Ford Hospital laboratory after excision.
次要结局
未报告次要终点
研究者
Iltefat Hamzavi
Dermatologist
Henry Ford Health System