Prevalence of Bacteria Following Endodontic Treatment

• Conditions: Root Canal Infection
• Interventions: Diagnostic Test: Detection of residual vital bacteria in the root canal space

• Registration Number: NCT03055975
• Lead Sponsor: King's College London

Brief Summary

Sampling of accessed root canals with endodontic paper points during treatment and immediately pre-obturation of endodontic root canals was carried out.

Detailed Description

Following ethical approval (REC ref: 05/Q0705/051), informed consent was obtained from patients undergoing root canal treatment.The teeth included in the study had been referred to a specialist centre for the treatment of endodontic infection. They all responded negatively to vitality tests and presented pre-operative apical radiolucencies. The source population were referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital, King's College London Dental Institute.Treatments on the teeth were carried out by a total of 19 postgraduate endodontic students.

Study Timeline

• Study Start: 2013-01-30
• Status Verified: 2017-02
• Study First Submitted: 2017-02-14
• Study First Submitted QC: 2017-02-14
• Study First Posted: 2017-02-16
• Last Update Submitted: 2017-02-16
• Last Update Posted: 2017-02-17
• Primary Completion: 2017-05-30
• Study Completion: 2018-10-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients with single or multi-rooted teeth undergoing root canal treatment.

Exclusion Criteria

• For certain aspects of the study secondary treatments and vital teeth are excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Primary treatments	Detection of residual vital bacteria in the root canal space	Patients undergoing primary root canal treatments. Only teeth which have not previously been accessed are included in this cohort.The source population are adults aged 18-65, referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital
Re-treatments	Detection of residual vital bacteria in the root canal space	Patients undergoing re-treatments. Only teeth which had a previous root canal treatment which failed are included in this cohort.The source population are adults aged 18-65, referred by their general dental practitioner into specialist endodontic clinics of Guy's Hospital

Primary Outcome Measures

Name	Time	Method
Detection of residual bacteria during and post root canal treatment	June 2016	Using a vital fluorescent stain bacteria sampled from the root canal space were detected during and post root canal treatment.

Trial Locations

Locations (1)

King's College London, Dental Institute, Floor 22, Endodontics; 🇬🇧 London, United Kingdom