Comparison of Loteprednol 0.5% with Fluorometholone 0.1% after Myopic Photorefractive Keratectomy (PRK)

Not Applicable

Conditions: intraocular pressure.
Glaucoma secondary to drugs

Registration Number: IRCT2016081629386N1

Lead Sponsor: Vice Chancellor Of Research, Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 62

Inclusion Criteria

age more than 18 years;
stable refraction for at least 12 month with myopia between -8.0 to -1.0 Diopters and astigmatism less than 4.0 Diopters;
normal eye examination (except refractive error);
corrected distance visual acuity (CDVA) of 20/20;
no history of systemic or autoimmune disease or receiving immunosuppressive treatment;
neither pregnant nor breast feeder;
using no topical ophthalmic medication;
have no contraindication for PRK.
Exclusion criteria:
Patients were unable to return for follow-up or needed to increase drug dosage for any reason;
patients who did not follow the instructions correctly;
patients with anisometropia (more than 1 diopter) or significant pre-operative central corneal thickness difference between two eyes (more than 20 µm); those who received MMC just in one eye;
patients with postoperative complications like keratitis.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intraocular pressure post photorefractive keratectomy. Timepoint: pre operation and 1,2,3 month post op. Method of measurement: Intraocular pressure was measured over central cornea by Goldmann applanation tonometer.

Secondary Outcome Measures

Name	Time	Method
Visual acuity. Timepoint: pre operative and 1,2,3 month post operatively. Method of measurement: Snellen chart.;Corneal haze. Timepoint: 3 month post operatively. Method of measurement: slit lamp examination.;Ocular surface side effects related to topical drugs including eye redness and eye discomfort. Timepoint: 3 month post operatively. Method of measurement: question.