The protective effect of levocetirizine on exercise induced airway obstruction in cold air.
- Conditions
- exercise induced airway obstruction10038716
- Registration Number
- NL-OMON32040
- Lead Sponsor
- Medisch Spectrum Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 24
- Clinical history of allergic rhinitis and/or allergic asthma.
- Age between 12 and 17 years.
- Ability to perform reproducible lung function tests, i.e. coefficient of the predicted value variation in 3 of 5 consecutive measurements < 5%.
- Maximal FEV1 greater than 70% of predicted value.
- Clinically stable period at least 3 weeks before the study period.
- Use of intranasal or systemic corticosteroids in the last 4 weeks prior to the study.
- Use of antihistamines, cromoglycates, anticholinergics in two weeks prior to the study.
- Use of intranasal or systemic corticosteroids, antihistamines, cromoglycates, anticholinergics, during the study.
- Use of long acting bronchodilators 24 hours before testing.
- Use of short acting bronchodilators 8 hours before testing.
- Other pulmonary or cardiac disorder.
- Deviation of the FEV1 of more than 12 % from baseline spirometry and the FEV1 before subsequent exercise provocation challenges.
- Signs of gastro-esophageal reflux.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The reduction in exercise induced fall of FEV1, MIF50 and increase in airway<br /><br>resistance after a single dose of LEV. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>