Retrospective Analysis of Sarcopenia in Older Patients Undergoing Laparotomy-

Emergency laparotomy is associated with substantial morbidity and mortality. These risks are increased in the elderly population with a third of over-80s dying within thirty days of surgery, rising to 50% at 1-year post emergency laparotomy. Many patients are frail and have multiple co-morbidities, often with coexistent malnutrition and so present a significant challenge in the emergency surgery setting. The National Emergency Laparotomy Audit has reported that greater than half of patients undergoing emergency laparotomy in the UK are over-65 years of age and are the highest risk patients with the highest mortality. This group, therefore, is one in which accurate prognostication is desirable to allow optimal treatment decisions, provision of critical care treatment, and resource allocation.

A number of multivariate risk prediction models exist including POSSUM, P-POSSUM and APACHE-II with on-going modification of P-POSSUM as part of the National Emergency Laparotomy Audit(NELA). Whilst such models are commonly used, evidence suggests that they may be less accurate in elderly patients, a group which offer difficult decision-making problems to the surgeon

. Frailty is the lack of physiological functional reserve and is commonplace in elderly patients. It has profound effects on the ability to withstand and recover from emergency surgery. Despite this, frailty does not form part of the commonly used multivariate risk prediction models.

Sarcopenia is the progressive and global loss of skeletal muscle mass as well as reduction in strength and is closely linked to frailty. Multiple methods of quantifying skeletal muscle mass and therefore sarcopenia have been defined, but calculation of psoas major cross-sectional area on pre-operative CT imaging may be the most pragmatic in the emergency setting due to routine use of pre-operative CT imaging prior to emergency laparotomy. Measurement of the psoas major as a marker of sarcopenia has been shown to predict outcomes in a wide range of surgical specialties. However, there is no consensus as to how this marker of sarcopenia should be used in surgical practice.

Proposal- To assess the utility of psoas major measurement to predict outcomes following emergency laparotomy in older patients and whether it could enhance the accuracy of mortality prediction when combined with P-POSSUM model variables.