Sarcopenia After Bariatric Surgery in Older Patients: a Cohort Study

Completed

• Conditions: Bariatric Surgery; Aging; Overweight and Obesity; Sarcopenic Obesity
• Interventions: Procedure: Bariatric surgery

• Registration Number: NCT05582668
• Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Brief Summary

The retrospective cohort study will compare the prevalence of sarcopenia and associated factors between older patients who have undergone bariatric surgery and older patients with obesity without previous bariatric surgery.

Detailed Description

The aim of the study is to compare the prevalence of sarcopenia and nutritional status between adults older than 65 years who have previously undergone bariatric surgery and patients with obesity but without previous bariatric surgery. Current sarcopenia will be assessed during a cross-sectional assessment after surgery using the criteria from the European Working Group on Sarcopenia in Older People (EWGSOP).

Study Timeline

• Study Start: 2022-10-03
• Study First Submitted: 2022-10-12
• Study First Submitted QC: 2022-10-12
• Study First Posted: 2022-10-17
• Primary Completion: 2024-07-14
• Study Completion: 2024-07-14
• Status Verified: 2024-10
• Last Update Submitted: 2025-02-21
• Last Update Posted: 2025-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Signed informed consent
• Age 65 years or older
• Cohort 1 (exposed): Previous bariatric surgery for obesity at least 1 one year ago
• Cohort 2 (unexposed): No previous weight loss surgery

Exclusion Criteria

• Current diagnosis of cancer
• Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4.
• Immobility
• Neuromuscular degenerative conditions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cohort 1	Bariatric surgery	Cohort 1: Older patients with overweight, obesity after bariatric surgery

Primary Outcome Measures

Name	Time	Method
The number of older patients with sarcopenia after bariatric surgery compared to non-surgical control patients.	At least one year post surgery	a) Sarcopenia will be classified according to the criteria form the European Working Group on Sarcopenia in Older People revised guidelines (EWGSOP2) based on skeletal muscle mass, muscle strength and physical performance criteria.

Secondary Outcome Measures

Name	Time	Method
3. Markers of chronic systemic inflammation in older patients after bariatric surgery compared to non-surgical control patients	At least one year post surgery	Inflammatory markers will include CRP, IL-1β, IL-6, IL-8, TNF-α
1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients	At least one year post surgery	1. Appendicular skeletal muscle mass older of patients after bariatric surgery compared to non-surgical control patients
2. The prevalence of nutrient deficiencies in older patients after bariatric surgery compared to non-surgical control patients.	At least one year post surgery	a. Indices of nutrient deficiencies will include reported dietary intake of protein, zinc, selenium, and blood levels of Vitamin D, zinc, and selenium.

Trial Locations

Locations (1)

Obesity Clinic University Hospitals Leuven; 🇧🇪 Leuven, Belgium