A Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Registration Number
- NCT03926130
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The reason for this study is to see if the study drug mirikizumab is safe and effective in participants with moderately to severely active Crohn's disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1158
- Diagnosis of CD for at least 3 months prior to baseline
- Confirmed diagnosis of moderate to severe CD as assessed by SF, AP score, and SES-CD
- Demonstrated intolerance, loss of response or inadequate response to conventional or to biologic therapy for CD
- If female, subject must meet the contraception recommendations
- Have a current diagnosis of ulcerative colitis, inflammatory bowel disease-unclassified (IBD-U) (formerly known as indeterminate colitis) or short bowel syndrome
- Currently have or are suspected to have an abscess. Recent cutaneous and perianal abscesses are not exclusionary if drained, adequately treated and resolved at least 3 weeks prior to baseline or 8 weeks prior to baseline for intra-abdominal abscesses, provided that there is no anticipated need for any further surgery
- Have a stoma, ileoanal pouch or ostomy
- Have had a bowel resection within 6 months, or any kind of intra-abdominal or extra abdominal surgery within 3 months of baseline
- Have ever received any monoclonal antibodies binding IL-23
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants received Placebo intravenously (IV) or subcutaneously (SC) every 4 weeks (Q4W). Any participant in the placebo arm who was considered a non-responder at Week 12 received 900 mg Mirikizumab IV Q4W for 3 doses, then 300 mg SC Q4W for the remainder of the study. Nonresponse is defined as failing to achieve at least a 30% decrease in stool frequency (SF) and/or abdominal pain (AP) and be no worse than baseline. 300 mg Mirikizumab Mirikizumab Participants received 900 milligrams (mg) Mirikizumab IV Q4W for 3 doses, then 300 mg SC Q4W 90 mg Ustekinumab Ustekinumab Participants received 6 mg/kg Ustekinumab IV for one dose, then 90 mg SC every 8 weeks (Q8W) 300 mg Mirikizumab (Adolescents) Mirikizumab Participants received open label 900 mg Mirikizumab IV for 3 doses, then 300 mg SC Q4W
- Primary Outcome Measures
Name Time Method Percentage of Adult Participants Achieving Clinical Response at Week 12 and Endoscopic Response at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical response by patient reported outcome (PRO) defined as ≥30% decrease in stool frequency (SF) and/or abdominal pain (AP) \& neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Endoscopic response defined as ≥50% reduction from baseline in total Simple Endoscopic Score for Crohn's Disease (SES-CD) score. SES-CD evaluates 4 variables assessed in 5 bowel segments, each scored from 0-3: presence \& size of ulcers (none=0; diameter 0.1-0.5 cm=1; 0.5-2 cm=2; \>2 cm=3); extent of ulcerated surface (none=0; \<10%=1; 10% to 30%=2; \>30%=3); extent of affected surface (none=0; \<50%=1; 50% to 75%=2; \>75%=3); presence \& type of narrowing (none=0; single, can be passed=1; multiple, can be passed=2; cannot be passed=3). Total is sum of all scores across all bowel segments. Scores range from 0 to 56, with higher scores indicating more severe disease.Percentage of Adult Participants Achieving Clinical Response at Week 12 and Clinical Remission at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical response by PRO defined as ≥ 30% decrease in SF and/or AP and neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Clinical remission defined as Crohn's Disease Activity Index (CDAI) total score \<150. The CDAI is an 8-item disease activity measure comprised of a composite of 3 patient-reported items: AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe); SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7; and general well-being (0=generally well, 1=slightly under par, 2=poor, 3=very poor, 4=terrible), and 5 physician-reported/laboratory items (physical signs and a laboratory parameter \[hematocrit\]).. Total score range of 0 to 600 points.
- Secondary Outcome Measures
Name Time Method Percentage of Adult Participants Achieving Endoscopic Response at Week 12 (Placebo and Mirikizumab) Week 12 Endoscopic Response defined as ≥50% reduction from baseline in SES-CD total score. SES-CD evaluates 4 variables assessed in 5 bowel segments, each scored from 0-3: presence \& size of ulcers (none = 0; diameter 0.1-0.5 cm = 1; 0.5-2 cm = 2; \>2 cm = 3); extent of ulcerated surface (none = 0; \<10% = 1; 10% to 30% = 2; \>30% = 3); extent of affected surface (none = 0; \<50% = 1; 50% to 75% = 2; \>75% = 3); presence \& type of narrowing (none = 0; single, can be passed = 1; multiple, can be passed = 2; cannot be passed = 3). Total is sum of all scores across all bowel segments. Scores range from 0 to 56, with higher scores indicating more severe disease.
Percentage of Adult Participants Achieving Endoscopic Response at Week 52 Week 52 Endoscopic Response defined as ≥50% reduction from baseline in SES-CD total score. SES-CD evaluates 4 variables assessed in 5 bowel segments, each scored from 0-3: presence \& size of ulcers (none = 0; diameter 0.1-0.5 cm = 1; 0.5-2 cm = 2; \>2 cm = 3); extent of ulcerated surface (none = 0; \<10% = 1; 10% to 30% = 2; \>30% = 3); extent of affected surface (none = 0; \<50% = 1; 50% to 75% = 2; \>75% = 3); presence \& type of narrowing (none = 0; single, can be passed = 1; multiple, can be passed = 2; cannot be passed = 3). Total is sum of all scores across all bowel segments. Scores range from 0 to 56, with higher scores indicating more severe disease.
Percentage of Adult Participants Achieving Clinical Remission at Week 12 (Placebo and Mirikizumab) Week 12 Clinical remission defined as CDAI total score \<150. The CDAI is an 8- item disease activity measure comprised of a composite of 3 patient-reported items: AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe); SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7; and general well-being (0=generally well, 1=slightly under par, 2=poor, 3=very poor, 4=terrible), and 5 physician-reported/laboratory items (physical signs and a laboratory parameter \[hematocrit\]). Total score range of 0 to 600 points.
Percentage of Adult Participants Achieving Clinical Remission at Week 52 Week 52 Clinical remission defined as CDAI total score \<150. The CDAI is an 8- item disease activity measure comprised of a composite of 3 patient-reported items: AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe); SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7; and general well-being (0=generally well, 1=slightly under par, 2=poor, 3=very poor, 4=terrible), and 5 physician-reported/laboratory items (physical signs and a laboratory parameter \[hematocrit\]). Total score range of 0 to 600 points.
Percentage of Adult Participants Achieving Endoscopic Remission at Week 12 (Placebo and Mirikizumab) Week 12 Endoscopic remission is defined as SES-CD Total Score ≤4 and at least a 2-point reduction from baseline and no subscore \>1. SES-CD evaluates 4 endoscopic variables in 5 bowel segments and each of the 20 individual variables is scored from 0-3: presence \& size of ulcers (none = 0; diameter 0.1-0.5 cm = 1; 0.5-2 cm = 2; \>2 cm = 3); extent of ulcerated surface (none = 0; \<10% = 1; 10% to 30% = 2; \>30% = 3); extent of affected surface (none = 0; \<50% = 1; 50% to 75% = 2; \>75% = 3); presence \& type of narrowing (none = 0; single, can be passed = 1; multiple, can be passed = 2; cannot be passed =3). Total is sum of all scores across all bowel segments. Scores range from 0 to 56, with higher scores indicating more severe disease. No subscore \>1 is defined as no segmental subscore (sum of the 4 individual variable scores for each of the 5 bowel segments) \>1.
Change From Baseline in Urgency Numeric Rating Scale (NRS) at Week 12 in Adult Participants (Placebo and Mirikizumab) Baseline, Week 12 The Urgency NRS is a single patient-reported item that measures the severity for the urgency (sudden or immediate need) to have a bowel movement in the past 24 hours using an 11-point NRS ranging from 0 (no urgency) to 10 (worst possible urgency).
Change From Baseline in Urgency NRS at Week 52 in Adult Participants (Placebo and Mirikizumab) Baseline, Week 52 The Urgency NRS is a single patient-reported item that measures the severity for the urgency (sudden or immediate need) to have a bowel movement in the past 24 hours using an 11-point NRS ranging from 0 (no urgency) to 10 (worst possible urgency).
Percentage of Adult Participants Achieving Clinical Response at Week 12 and Clinical Remission by PRO at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical Response by PRO defined as ≥30% decrease in SF and/or AP \& neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Clinical Remission by PRO defined as SF≤3 and not worse than baseline (as per Bristol Stool Scale Category 6 or 7) and AP ≤1 and no worse than baseline.Percentage of Adult Participants Achieving Clinical Response at Week 12 and Endoscopic Remission at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical Response by PRO defined as ≥30% decrease in SF and/or AP \& neither score worse than baseline. SF (number of liquid or very soft stools) per Bristol Stool Scale Category 6 or 7 \& AP (4-point scale:0=none,1=mild,2=moderate,3=severe). Endoscopic remission=SES-CD Total Score ≤4 \& at least 2-point reduction from baseline \& no subscore \>1.SES-CD evaluates 4 endoscopic variables in 5 bowel segments \& each of 20 individual variables scored 0-3: presence \& size of ulcers (none=0;diameter 0.1-0.5 cm=1;0.5-2 cm=2;\>2 cm=3);extent of ulcerated surface (none=0;\<10%=1;10% to 30%=2;\>30%=3);extent of affected surface (none=0;\<50%=1;50% to 75%=2;\>75%=3);presence \& type of narrowing (none=0;single,can be passed=1;multiple,can be passed=2;cannot be passed=3). Total is sum of all scores across all bowel segments. Scores range from 0 to 56;higher scores indicating more severe disease. No subscore \>1=no segmental subscore (sum of the 4 individual variable scores for each of the 5 bowel segments) \>1
Percentage of Adult Participants Achieving Clinical Response at Week 12 and Corticosteroid-free Clinical Remission at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical response by PRO defined as ≥30% decrease in SF and/or AP and neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Clinical remission defined as CDAI total score \<150. The CDAI is an 8- item disease activity measure comprised of a composite of 3 patient-reported items: AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe); SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7; and general well-being (0=generally well, 1=slightly under par, 2=poor, 3=very poor, 4=terrible), and 5 physician-reported/laboratory items (physical signs and a laboratory parameter \[hematocrit\]). Total score range of 0 to 600 points.
Corticosteroid-free clinical remission by CDAI is defined as achieving clinical remission by CDAI at Week 52 and being corticosteroid free from Week 40 to Week 52.Change From Baseline in C-Reactive Protein (CRP) at Week 52 in Adult Participants (Placebo and Mirikizumab) Baseline, Week 52 Change from baseline in CRP
Change From Baseline in Fecal Calprotectin at Week 52 in Adult Participants (Placebo and Mirikizumab) Baseline, Week 52 Change from baseline in Fecal Calprotectin
Percentage of Adult Participants Achieving Clinical Response at Week 12 and Resolution of Baseline Extraintestinal Manifestations (EIMs) at Week 52 (Placebo and Mirikizumab) Week 12 to Week 52 Clinical response by PRO defined as ≥30% decrease in SF and/or AP and neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Percentage of Adult Participants Achieving Clinical Response at Week 12 and ≥50% Reduction in Number of Draining Cutaneous Fistulae at Week 52 in Participants With Draining Cutaneous Fistulae at Baseline (Placebo and Mirikizumab) Week 12 to Week 52 Clinical response by PRO defined as ≥ 30% decrease in SF and/or AP and neither score worse than baseline. SF (number of liquid or very soft stools) as per Bristol Stool Scale Category 6 or 7 and AP (4-point scale: 0=none, 1=mild, 2=moderate, 3=severe).
Change From Baseline in Health Related Quality of Life at Week 52 in Adult Participants: Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score (Placebo and Mirikizumab) Baseline, Week 52 The IBDQ is a 32-item patient completed questionnaire that measures 4 aspects of patients' lives: symptoms directly related to the primary bowel disturbance, systemic symptoms, emotional function, and social function. Responses are graded on a 7-point Likert scale in which 7 denotes "not a problem at all" and 1 denotes "a very severe problem." IBDQ total score is calculated as the sum of all questions. Scores range from 32 to 224; a higher score indicates a better quality of life.
Adult Population Pharmacokinetics (PopPK): Area Under the Concentration Time Curve (AUC) of Mirikizumab 900 mg Mirikizumab: Week 4: Predose; Week 4, Day 1: Postdose; Week 8, 12: Predose 300 mg Mirikizumab: Week 16, 24, 36: Predose; Week 52 PopPK: AUC of Mirikizumab
Trial Locations
- Locations (571)
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Digestive Health Specialists
🇺🇸Tupelo, Mississippi, United States
GastroIntestinal Biosciences Clinical Trials
🇺🇸Los Angeles, California, United States
Digestive Healthcare of Georgia
🇺🇸Atlanta, Georgia, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases
🇺🇸Dallas, Texas, United States
Ohio State University Hospital
🇺🇸Columbus, Ohio, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
CEMIC- Servicio de Reumatología
🇦🇷Caba, Buenos Aires, Argentina
Instituto Medico Elsa Perez SRL (IMEP)
🇦🇷Ciudadela, Buenos Aires, Argentina
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Buenos Aires, Argentina
Coastal Digestive Health
🇦🇺Maroochydore, Queensland, Australia
Krankenhaus der Barmherzigen Schwestern Wien
🇦🇹Wien, Austria
AKH
🇦🇹Wien, Austria
Hospital Gloria Dor
🇧🇷Rio de Janeiro, Brazil
Baylor College of Medicine
🇺🇸Houston, Texas, United States
University of Texas Health Services Center - Houston
🇺🇸Houston, Texas, United States
The First People's Hospital of Foshan
🇨🇳Foshan, Guangdong, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
The Sixth Affiliated Hospital, Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China
Xiangya Hospital Central South University
🇨🇳Changsha, Hunan, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
Clinical Medical Centre Osijek
🇭🇷Osijek, Croatia
Synexus Czech
🇨🇿Prague, Praha 2, Czechia
Institut Klinicke a Experimentalni Mediciny
🇨🇿Praha 4, Prague, Czechia
Nemocnice Tomase Bati ve Zline
🇨🇿Zlín, Zlínský Kraj, Czechia
Thomayerova nemocnice
🇨🇿Prague, Praha 4, Czechia
PreventaMed, s.r.o.
🇨🇿Olomouc, Czechia
CHRU de Montpellier-Hopital St Eloi
🇫🇷Montpellier Cedex 5, France
CHU Charles Nicolle in Rouen
🇫🇷Rouen cedex, France
Bugát Pál Kórház
🇭🇺Gyöngyös, Hungary
Azienda Ospedaliera Di Rilievo Nazionale A. Cardarelli
🇮🇹Napoli, Italy
Maebashi Red Cross Hospital
🇯🇵Maebashi, Gunma, Japan
Health Pharma Professional Research S.A. de C.V:
🇲🇽Ciudad de México, Distrito Federal, Mexico
Olla-Med
🇷🇺Moscow, Moskva, Russian Federation
Affidea Medical Research Center
🇷🇴Constanta, Romania
The University Clinic of OSMU
🇷🇺Omsk, Russian Federation
University Medical Center "Bezanijska kosa"
🇷🇸Belgrade, NAP, Serbia
General Hospital "Djordje Joanovic"
🇷🇸Zrenjanin, Vojvodina, Serbia
Gastro LM s.r.o.
🇸🇰Presov, Slovakia
Clínica Gaias - Santiago
🇪🇸Santiago de Compostela, A Coruña [La Coruña], Spain
Eskisehir Osmangazi University Gastroenterology
🇹🇷Eskisehir, Turkey
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
🇹🇷Gaziantep, Turkey
Mustafa Kemal Universitesi Tayfur Ata Sokmen Tip Fakultesi
🇹🇷Hatay, Turkey
Fulya Acıbadem
🇹🇷Istanbul, Turkey
Dokuz Eylül Üniversitesi
🇹🇷Izmir, Turkey
Erciyes University Hospital
🇹🇷Kayseri, Turkey
Kocaeli University Medical Faculty Hospital
🇹🇷Izmit, Turkey
Konya Necmettin Erbakan Gastroenterology
🇹🇷Konya, Turkey
Polic.Umberto I -Univ. La Sapienza
🇮🇹Roma, Italy
ETG Zamość
🇵🇱Zamosc, Poland
Anhui Provincial Hospital
🇨🇳Hefei, Anhui, China
The Affiliated 2nd Hosp. of Third Military Med. Univ. of PLA
🇨🇳Chongqing, Chongqing, China
The First Hospital Affiliated to AMU (Southwest Hospital)
🇨🇳Chongqing, Chongqing, China
Affiliated Hospital of Jiangsu University
🇨🇳Zhenjiang, Jiangsu, China
Zhongshan Hospital, Fudan University
🇨🇳Shanghai, Shanghai, China
Shanghai 6th people's hospital
🇨🇳Shanghai, Shanghai, China
First Affiliated Hosp of College of Med, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China
Hôpital Beaujon
🇫🇷Clichy, Paris, France
Policlinico Gemelli - Università Cattolica del Sacro Cuore
🇮🇹Roma, Lazio, Italy
NZOZ Vivamed
🇵🇱Warsaw, Mazowieckie, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
🇵🇱Knurow, Poland
Novosibirski Gastrocenter
🇷🇺Novosibirsk, Novosibirskaya Oblast', Russian Federation
Scientific research center ECO-security
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
LLC "Medicine Center SibNovoMed"
🇷🇺Novosibirsk, Russian Federation
Cliagen - Clinica de Atencao em Gastroenterologia, Especialidades e Nutricao
🇧🇷Salvador, Bahia, Brazil
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
L2IP - Instituto de Pesquisas Clinicas Ltda.
🇧🇷Brasília, Distrito Federal, Brazil
Eurolatino Pesquisas Medicas Ltda.
🇧🇷Uberlandia, Minas Gerais, Brazil
All India Institute of Medical Sciences
🇮🇳New Delhi, Delhi, India
Sir Ganga Ram Hospital
🇮🇳New Delhi, Delhi, India
Apollo Speciality Hospital - Teynampet
🇮🇳Chennai, Tamil Nadu, India
Johanna Etienne Krankenhaus-Klinik für Allgemeine Innere Medizin
🇩🇪Neuss, North Rhine-Westphalia, Germany
Universitaetsklinikum Essen
🇩🇪Essen, North Rhine-Westphalia, Germany
RED-Institut GmbH
🇩🇪Oldenburg, Schleswig-Holstein, Germany
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Practice Dr.med. Denger and Dr.med. Pfitzner
🇩🇪Friedrichsthal, Saarland, Germany
Gemeinschaftspraxis Jakobeit
🇩🇪Wipperfurth, North Rhine-Westphalia, Germany
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Instituto de Pesquisa em Saúde - Fundação Universidade de Caxias do Sul
🇧🇷Caxias do Sul, Rio Grande Do Sul, Brazil
Columbus Clinical Services, LLC
🇺🇸Miami, Florida, United States
Infinite Clinical Research
🇺🇸Miami, Florida, United States
Nickalus Children's Hospital Research Institute
🇺🇸Miami, Florida, United States
Research Associates of South Florida, LLC
🇺🇸Miami, Florida, United States
Coral Research Clinic Corp
🇺🇸Miami, Florida, United States
SaludMax Medical Corp
🇺🇸Miami, Florida, United States
Ezy Medical Research
🇺🇸Miami, Florida, United States
Indiana University Health
🇺🇸Indianapolis, Indiana, United States
Advanced Biomedical Research of America - South Eastern Avenue
🇺🇸Las Vegas, Nevada, United States
Sun Research Institute
🇺🇸San Antonio, Texas, United States
VIP Trials
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC
🇺🇸San Antonio, Texas, United States
Care Access Research LLC - Salt Lake City
🇺🇸Salt Lake City, Utah, United States
Kalo Clinical Research
🇺🇸Salt Lake City, Utah, United States
Aalborg Hospital
🇩🇰Aalborg, Denmark
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
University of Alabama-The Kirklin Clinic
🇺🇸Birmingham, Alabama, United States
Arizona Arthritis & Rheumatology Research, PLLC
🇺🇸Phoenix, Arizona, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Chronos Pesquisa Clínica
🇧🇷Brasília, Distrito Federal, Brazil
Care Access Research - Tuscaloosa
🇺🇸Tuscaloosa, Alabama, United States
Lakeview Clinical Research
🇺🇸Guntersville, Alabama, United States
Central Arizona Medical Associates, PC
🇺🇸Mesa, Arizona, United States
Research Solutions of Arizona
🇺🇸Litchfield Park, Arizona, United States
Synexus Site Network
🇺🇸Tempe, Arizona, United States
Reliance Research
🇺🇸Scottsdale, Arizona, United States
inSite Digestive Health Care
🇺🇸Pasadena, California, United States
Newport Huntington Med Grp
🇺🇸Huntington Beach, California, United States
Care Access - Gilroy
🇺🇸Gilroy, California, United States
B G Clinical Research, Inc.
🇺🇸Encinitas, California, United States
California Medical Research Associates
🇺🇸Northridge, California, United States
Wolverine Clinical Trials, LLC
🇺🇸Santa Ana, California, United States
University of California Irvine
🇺🇸Orange, California, United States
Fomat Medical Research, Inc.
🇺🇸Thousand Oaks, California, United States
Connecticut Gastroenterology
🇺🇸Manchester, Connecticut, United States
Gastroenterology Consultants of Clearwater
🇺🇸Clearwater, Florida, United States
IMR of South Florida
🇺🇸Aventura, Florida, United States
West Central Gastroenterology d/b/a Gastro Florida
🇺🇸Clearwater, Florida, United States
C2 Research Center, LLC
🇺🇸Jacksonville, Florida, United States
Inpatient Research Clinic
🇺🇸Hialeah, Florida, United States
Doral Medical Research
🇺🇸Hialeah, Florida, United States
Florida Research Institute
🇺🇸Lakewood Ranch, Florida, United States
Central Florida Gastro Research
🇺🇸Kissimmee, Florida, United States
Goji Group - Research Trials Group
🇺🇸Miami Lakes, Florida, United States
Wellness Clinical Research
🇺🇸Miami Lakes, Florida, United States
Synexus Clinical Research US, Inc.
🇺🇸Pinellas Park, Florida, United States
Gastroenterology Associates of Pensacola, PA
🇺🇸Pensacola, Florida, United States
USPA Advance Concept Medical Research Group LLC.
🇺🇸South Miami, Florida, United States
Precision Clinical Research
🇺🇸Sunrise, Florida, United States
Advanced Research
🇺🇸Tamarac, Florida, United States
Grady Memorial Hospital
🇺🇸Atlanta, Georgia, United States
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
Gastrointestinal Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Grand Teton Research Group
🇺🇸Idaho Falls, Idaho, United States
Eagle Clinical Research
🇺🇸Chicago, Illinois, United States
Care Access Research - Terre Haute
🇺🇸Terre Haute, Indiana, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
CroNola LLC
🇺🇸Houma, Louisiana, United States
Delta Research Partners LLC
🇺🇸Monroe, Louisiana, United States
MGG Group, Inc.., Co., Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Capital Digestive Care
🇺🇸Rockville, Maryland, United States
Louisiana Clinical Research, LLC
🇺🇸Shreveport, Louisiana, United States
Woodholme Gastroenterology Associates - Glen Burnie
🇺🇸Glen Burnie, Maryland, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Revive Research Institute
🇺🇸Farmington Hills, Michigan, United States
Infusion Associates
🇺🇸Grand Rapids, Michigan, United States
MNGI Digestive Health, P.A.
🇺🇸Plymouth, Minnesota, United States
Southern Therapy and Advanced Research (STAR) LLC
🇺🇸Jackson, Mississippi, United States
BVL Research
🇺🇸Liberty, Missouri, United States
Gastrointestinal Associates
🇺🇸Flowood, Mississippi, United States
University of Mississippi School of Medicine
🇺🇸Jackson, Mississippi, United States
Care Access - Las Vegas
🇺🇸Las Vegas, Nevada, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸Lake Success, New York, United States
Care Access Research - Yonkers
🇺🇸Yonkers, New York, United States
Javara
🇺🇸Charlotte, North Carolina, United States
Peters Medical Research
🇺🇸High Point, North Carolina, United States
Medication Management
🇺🇸Greensboro, North Carolina, United States
Care Access Research-Kinston
🇺🇸Kinston, North Carolina, United States
Care Access Research-Lumberton
🇺🇸Lumberton, North Carolina, United States
Care Access Research - Scranton
🇺🇸Scranton, Pennsylvania, United States
Northshore Gastroenterology Research, LLC
🇺🇸Westlake, Ohio, United States
University Gastroenterology
🇺🇸Providence, Rhode Island, United States
Care Access Research LLC
🇺🇸Pottsville, Pennsylvania, United States
Strand GI
🇺🇸Myrtle Beach, South Carolina, United States
Gastroenterology Associates of Orangeburg
🇺🇸Orangeburg, South Carolina, United States
GIA Clinical Trials, LLC
🇺🇸Knoxville, Tennessee, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
Advanced Gastroenterology Associates
🇺🇸Decatur, Texas, United States
Caprock Gastro Research, LLC
🇺🇸Lubbock, Texas, United States
Biopharma Informatic, LLC
🇺🇸McAllen, Texas, United States
Katy Gastro Health & Nutrition
🇺🇸Katy, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Digestive System Healthcare
🇺🇸Pasadena, Texas, United States
Children's Specialty Group, PPLC
🇺🇸Norfolk, Virginia, United States
Velocity Clinical Research/Gut Whisperer
🇺🇸Riverton, Utah, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
Pediatrics Specialists of Virginia
🇺🇸Fairfax, Virginia, United States
The Center for Gastrointestinal Health
🇺🇸Petersburg, Virginia, United States
Virginia Gastroenterology Institute
🇺🇸Suffolk, Virginia, United States
Carilion Clinic
🇺🇸Roanoke, Virginia, United States
Washington Gastroenterology, PLLC
🇺🇸Tacoma, Washington, United States
TPMG Clinical Research Williamsburg
🇺🇸Williamsburg, Virginia, United States
Advanced Clinical Research-Spokane Gastroenterology
🇺🇸Spokane, Washington, United States
Care Access Research - Wyoming
🇺🇸Casper, Wyoming, United States
Marshall Medical Center
🇺🇸Huntington, West Virginia, United States
DOM- Centro de Reumatologia
🇦🇷Caba, Buenos Aires, Argentina
CIPREC
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autónoma De Buenos Aire, Argentina
Mautalen Salud e Investigación
🇦🇷Caba, Buenos Aires, Argentina
Centro de Investigaciones Médicas Tucuman
🇦🇷SAN M. DE Tucuman, Tucumán, Argentina
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
St. Vincents Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Emeritus Research
🇦🇺Camberwell, Victoria, Australia
Northern Hospital
🇦🇺Epping, Victoria, Australia
Coral Sea Clinical Research Institute
🇦🇺North Mackay, Queensland, Australia
The Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Universitätsklinikum Salzburg
🇦🇹Salzburg, Austria
Imelda General Hospital
🇧🇪Bonheiden, Antwerpen, Belgium
UZ Brussel
🇧🇪Brussel, Belgium
AZ Groeninge
🇧🇪Kortrijk, Belgium
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
🇧🇪Leuven, Belgium
HUWC - UFC - Hospital Universitário Walter Cantídio - Universidade Federal do Ceará
🇧🇷Fortaleza, Ceara, Brazil
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda
🇧🇷Goiania, GO, Brazil
Hospital Felício Rocho
🇧🇷Belo Horizonte, MG, Brazil
Associacao Paranaense de Cultura - PUCPR
🇧🇷Curitiba, Parana, Brazil
Nucleo de Pesquisa Clínica do Rio Grande do Sul-NPCRS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Moinhos de Vento
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Pesquisare
🇧🇷Santo Andre, Sao Paulo, Brazil
HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas
🇧🇷Campinas, Sao Paulo, Brazil
Faculdade de Medicina de Botucatu
🇧🇷Botucatu, SP, Brazil
Faculdade de Medicina do ABC
🇧🇷Santo Andre, SP, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clinicos EPP Ltda
🇧🇷São Bernardo do Campo, São Paulo, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estudo Estadual
🇧🇷Sao Paulo, SP, Brazil
Praxis Pesquisa Medica
🇧🇷Santo Andre, São Paulo, Brazil
Hospital Sírio Libanês
🇧🇷Sao Paulo, Brazil
Hepatogastro
🇧🇷Sao Paulo, Brazil
CPQuali Pesquisa Clínica
🇧🇷São Paulo, Brazil
Clinica Onco Star
🇧🇷São Paulo, Brazil
Fraser Clinical Trials Inc
🇨🇦New Westminster, British Columbia, Canada
The Medical Arts Health Research Group
🇨🇦North Vancouver, British Columbia, Canada
GI Research Institute
🇨🇦Vancouver, British Columbia, Canada
Milestone Clinical
🇨🇦Dartmouth, Nova Scotia, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
K&M Medical
🇨🇦Kentville, Nova Scotia, Canada
Victoria Hospital
🇨🇦London, Ontario, Canada
Viable Clinical Research
🇨🇦Sudbury, Ontario, Canada
CIUSS-de-L'Est-de-l'île-de-Montréal-Hôpital
🇨🇦Montreal, Quebec, Canada
Peking University First Hospital
🇨🇳Beijing, Beijing, China
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fujian, Fuzhou, China
Chongqing General Hospital
🇨🇳Chongqing, Chongqing, China
First affiliated Hospital of Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China
Hainan General Hospital
🇨🇳Haikou, Hainan, China
Tongji Hosp Tongji Med Col Huazhong Univ of Sci & Tech
🇨🇳Wu Han, Hubei, China
Jiangsu Province Hospital
🇨🇳Nanjing, Jiangsu, China
The Third Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The First People's Hospital of Changzhou
🇨🇳Changzhou, Jiangsu, China
Changzhou No.2 People's Hospital
🇨🇳Changzhou, Jiangsu, China
Jiangsu Province Hospital of Chinese Medicine
🇨🇳Nanjing, Jiangsu, China
The Second Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
Wuxi People's Hospital
🇨🇳Wuxi, Jiangsu, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Shanghai East Hospital
🇨🇳Shanghai, Pudong District, China
West China Hospital of Sichuan University
🇨🇳Cheng Du, Sichuan, China
Shanghai Jiaotong University School of Medicine Ruijin Hospital
🇨🇳Shanghai, Shanghai, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
First Affiliated Hospital of Kunming Medical University
🇨🇳Kunming, Yunnan, China
The First People's Hospital of Yunnan Province
🇨🇳Kunming, Yunnan, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated Hospital YuYing Childens Hospital of Wenzhou Medical university
🇨🇳Wenzhou, Zhejiang, China
Zhongshan Hospital Xiamen University
🇨🇳Xiamen, China
CHC Zagreb
🇭🇷Zagreb, Croatia
Vojenská Nemocnice Brno
🇨🇿Brno, Brno-město, Czechia
Krajska zdravotni, a.s.-Masarykova nemocnice Usti nad Labem
🇨🇿Usti nad Labem, Czech Republic, Czechia
MUDr. Gregar, s.r.o.
🇨🇿Olomouc, Olomoucký Kraj, Czechia
Hepato-Gastroenterologie HK
🇨🇿Hradec Kralove, Hradec Králové, Czechia
Oblastni nemocnice Nachod-Endoskopicke centrum
🇨🇿Nachod, Czechia
Fakultni Nemocnice U svate Anny
🇨🇿Brno, Czechia
AXON Clinical
🇨🇿Praha 5, Czechia
MUDr. Radka Koskova, s.r.o., Gastroenterologicka ambulance
🇨🇿Ostrava - Muglinov, Czechia
A-Shine, s.r.o.
🇨🇿Plzen, Czechia
ISCARE Clinical Centre
🇨🇿Praha 9, Czechia
Mediendo, s.r.o.
🇨🇿Praha 8, Czechia
Aarhus Universitetshospital, Skejby
🇩🇰Aarhus, Midtjylland, Denmark
CHU Amiens Picardie Site Sud - Service d'Hepato-gastro-entérologie
🇫🇷Amiens, France
Hopital de Hautepierre - Service d'Hépatogastroentérolgie
🇫🇷Strasbourg Cedex, Bas Rhin, France
Hôpital Saint Antoine
🇫🇷Paris, Cedex 12, France
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre
🇫🇷Le Kremlin-Bicêtre, Paris, France
Centre Hospitalier du Mans
🇫🇷Le Mans, France
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud -
🇫🇷Pierre Benite cedex, Rhone, France
GH Necker - Enfants Malades
🇫🇷Paris, France
CHU de Poitiers- Service d'Hépato-gastro-entérologie,
🇫🇷Poitiers Cedex, France
CHU Bordeaux - Hôpital Haut-Lévêque
🇫🇷Pessac Cedex, France
CHU St Etienne Hopital Nord
🇫🇷Saint Etienne Cedex 2, France
CHRU de Nancy
🇫🇷Vand?uvre-lès-Nancy, France
Siloah St. Trudpert Klinikum-Zentrum für Innere Medizin
🇩🇪Pforzheim, Baden-Württemberg, Germany
Universitätsklinikum Würzburg A. ö. R.
🇩🇪Würzburg, Bayern, Germany
Synexus Clinical Research GmbH
🇩🇪Berlin, Germany
Krankenhaus Eichhof
🇩🇪Lauterbach, Hessen, Germany
Medizinische Hochschule Hanover
🇩🇪Hannover, Niedersachsen, Germany
Knappschaftskrankenhaus Bottrop
🇩🇪Bottrop, Nordrhein Westfalen, Germany
St. Marienkrankenhaus-Medizinische Klinik I
🇩🇪Ludwigshafen, Rhineland-Palatinate, Germany
Studiengesellschaft BSF Unternehmergesellschaft
🇩🇪Halle (Saale),, Sachsen Anhalt, Germany
HaFCED - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen
🇩🇪Hamburg, Germany
Synexus Clinical Research GmbH-Leipzig Research Centre
🇩🇪Leipzig, Saxony-Anhalt, Germany
Florence-Nightingale-Krankenhaus
🇩🇪Düsseldorf, Germany
Universitätsklinikum Schleswig-Holstein
🇩🇪Kiel, Schleswig-Holstein, Germany
Gastroenterologische Gemeinschaftspraxis Mainz
🇩🇪Mainz, Germany
Charité Campus Virchow-Klinikum
🇩🇪Berlin, Germany
Synexus Gyula
🇭🇺Gyula, Bekes, Hungary
Tumorzentrum Nordthüringen
🇩🇪Uslar, Germany
SZTE AOK Belgyogyaszati Klinika
🇭🇺Szeged, Csongrad, Hungary
Clinexpert SMO
🇭🇺Budapest, Hungary
Clinexpert Tatabánya Ltd.
🇭🇺Tatabánya, Komárom-Esztergom, Hungary
DRC Gyogyszervizsgalo Kozpont Kft.
🇭🇺Balatonfüred, EU, Hungary
Synexus Magyarorszag Kft.
🇭🇺Budapest, Hungary
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház
🇭🇺Békéscsaba, Hungary
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
Endomedix Diagnosztikai Központ - Miskolc
🇭🇺Miskolc, Hungary
CLINFAN Szolgáltató Kft
🇭🇺Szekszard, Hungary
Gujarat Hospital - Gastro and Vascular Centre
🇮🇳Surat, Gujarat, India
Aakash Healthcare Super Speciality Hospital
🇮🇳New Delhi, India
International Gastro Institute
🇮🇳Vadodara, Gujarat, India
Midas Multispeciality Hospital Pvt.Ltd.
🇮🇳Nagpur, Maharashtra, India
Ruby Hall Clinic and Grant Medical Foundation
🇮🇳Pune, Maharashtra, India
SR Kalla Memorial Gastro & General Hospital
🇮🇳Jaipur, Rajasthan, India
Asian Institute of Gastroenterology
🇮🇳Hyderabad, Telangana, India
Dayanand Medical College and Hospital
🇮🇳Ludhiana, Punjab, India
Postgraduate Institute of Medical Education & Research
🇮🇳Chandigarh, India
Yashoda Super Speciality Hospital
🇮🇳Telangana, India
Gandhi Hospital
🇮🇳Telangana, India
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Soroka Medical Center
🇮🇱Beer Sheva, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Edith Wolfson Medical Center
🇮🇱Holon, Israel
Hadassah Medical Center
🇮🇱Jerusalem, Israel
Galilee Medical Center Department of Internal Medicine A
🇮🇱Nahariya, Israel
Azienda Ospedaliera Universitaria Policlinico de Modena
🇮🇹Modena, Italy
Kaplan Medical Center
🇮🇱Rehovot, Israel
Azienda Ospedaliera Saverio De Bellis
🇮🇹Castellana Grotte, Bari, Italy
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Università di Cagliari - Presidio Policlinico Monserrato
🇮🇹Monserrato, Cagliari, Italy
Assaf Harofeh Medical Center
🇮🇱Zerifin, Israel
Azienda ospedaliero-universitaria Mater Domini
🇮🇹Germaneto, Catanzaro, Italy
Presidio di Rho
🇮🇹Rho, Milano, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
Ospedale Clinicizzato San Donato
🇮🇹San Donato Milanese, Milan, Italy
Istituto Mangiagalli
🇮🇹Milano, MI, Italy
Università degli Studi c/o Spedali Civili
🇮🇹Brescia, Italy
Azienda Ospedaliera Policlinico Consorziale
🇮🇹Bari, Italy
Azienda Ospedaliera Giuseppe Brotzu
🇮🇹Cagliari, Italy
Ospedale Luigi Sacco
🇮🇹Milano, Italy
Azienda Ospedaliera Santa Maria Della Misericordia
🇮🇹Udine, Italy
Azienda Ospedaliera Universitaria Federico II
🇮🇹Napoli, Italy
Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Italy
Kojunkai Daido Clinic
🇯🇵Nagoya, Aichi, Japan
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Aomori, Japan
Tsujinaka Hospital
🇯🇵Kashiwa, Chiba, Japan
Hoshi General Hospital
🇯🇵Koriyama, Fukushima, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Fukuoka, Japan
Kiryu Kosei Hospital
🇯🇵Kiryu, Gunma, Japan
Isesakishimin Hospital
🇯🇵Isesaki, Gunma, Japan
National Hospital Organization Fukuyama Medical Center
🇯🇵Fukuyama, Hiroshima, Japan
Asahikawa Medical College Hospital
🇯🇵Asahikawa, Hokkaido, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Hokkaido, Japan
Tokushukai Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Chuo-ku, Sapporo-shi, Hokkaido, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Hyogo College of Medicine
🇯🇵Nishinomiya, Hyogo, Japan
Ibaraki Prefectural Central Hospital
🇯🇵Kasama, Ibaraki, Japan
Ofuna Central Hospital
🇯🇵Kamakura, Kanagawa, Japan
Mie University Hospital
🇯🇵Tsu, Mie, Japan
Matsushima Cinic
🇯🇵Yokohama, Kanagawa, Japan
Kitasato University Hospital
🇯🇵Sagamihara, Kanagawa, Japan
Takagi Clinic - Sendai
🇯🇵Sendai, Miyagi, Japan
IMS Meirikai Sendai General Hospital
🇯🇵Sendai, Miyagi, Japan
Nagasaki Harbor Medical Center
🇯🇵Nagasaki City, Nagasaki, Japan
Saga-Ken Medical Center Koseikan
🇯🇵Saga-shi, Saga, Japan
Infusion Clinic
🇯🇵Osaka-shi, Osaka-Fu, Japan
Matsuda Hospital
🇯🇵Hamamatsu-shi, Shizuoka-Ken, Japan
Showa University Koto Toyosu Hospital
🇯🇵Koto-ku, Tokyo, Japan
Tottori University Hospital
🇯🇵Yonago, Tottori, Japan
Tokyo Medical and Dental University Hospital
🇯🇵Bunkyō, Tokyo, Japan
National Center for Global Health and Medicine
🇯🇵Shinjuku-ku, Tokyo, Japan
JHCO Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Tokyo, Japan
Jichi Medical University Hospital
🇯🇵Shimotsuke, Tochigi, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
Sameshima Hospital
🇯🇵Kagoshima, Japan
Kyoto Furitsu Medical University Hospital
🇯🇵Kyoto, Japan
Okayama Saiseikai General Hospital Outpatient Center
🇯🇵Okayama, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
Tokitokai Tokito Clinic
🇯🇵Saitama, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama, Japan
Ajou University Hospital
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of
Hanyang University Guri Hospital
🇰🇷Guri-si, Gyeonggido, Korea, Republic of
Kyung Pook National University Hospital
🇰🇷Daegu, Korea, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Korea, Republic of
Kyunghee University Hospital at Gangdong
🇰🇷Seoul, Korea, Korea, Republic of
Yeungnam Univeristy Medical Center
🇰🇷Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of
The Catholic University of Korea, Daejeon St. Mary's Hospital
🇰🇷Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Kyungpook National University Medical Center Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Keimyung University Dongsan Hospital
🇰🇷Daegu, Korea, Republic of
Korea University Ansan Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Gangwon-do, Korea, Republic of
Pauls Stradins Clinical Univeristy Hospital
🇱🇻Riga, Rīga, Latvia
Chungang University Hospital
🇰🇷Seoul, Korea, Republic of
Hospital of Lithuanian University of Health Sciences Kaunas
🇱🇹Kaunas, Lithuania
PanAmerican Clinical Research S.A.de C.V. Guadalajara
🇲🇽Guadalajara, JA, Mexico
Grupo Medico Camino Sc
🇲🇽México City, Distrito Federal, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo Leon, Mexico
PanAmerican Clinical Research Mexico S.A. de C.V.
🇲🇽Santiago de Queretaro, Queretaro, Mexico
Instituto de Investigaciones Clínicas para la Salud
🇲🇽Durango, Mexico
Scientia Investigacion Clinica S.C.
🇲🇽Chihuahua, Mexico
Sociedad de Metabolismo y Corazon
🇲🇽Veracruz, Mexico
Centro de Alta Especialidad Reumatologia Inv del Potosi SC
🇲🇽San Luis Potosi, Mexico
Bernhoven Uden
🇳🇱Uden, Netherlands
ETZ Elisabeth Tilburg
🇳🇱Tilburg, North Brabant, Netherlands
Melita Medical
🇵🇱Wroclaw, Dolnośląskie, Poland
MED-ROZ
🇵🇱Karwiany, Dolnośląskie, Poland
M. Sklodowskiej-Curie 12
🇵🇱Wroclaw, Lower Silesian, Poland
Dc-Med. Sp. z o.o.
🇵🇱Swidnica, Lower Silesian, Poland
ZOZ Gastromed
🇵🇱Lublin, Lubelskie, Poland
Topolowa Medicenter
🇵🇱Krakow, Małopolskie, Poland
Medicenter Nowy Targ
🇵🇱Nowy Targ, Małopolskie, Poland
NZOZ Formed
🇵🇱Wadowice, Małopolskie, Poland
Private Practice - Dr. Korczowski Bartosz
🇵🇱Rzeszow, Podkarpackie, Poland
Nova Reuma Społka Partnerska
🇵🇱Bialystok, Podlaskie, Poland
Synexus Polska Gdansku
🇵🇱Gdansk, Pomorskie, Poland
Endoskopia Sp. z.o.o.
🇵🇱Sopot, Pomorskie, Poland
Sonomed Sp. z o.o.
🇵🇱Szczecin, West Pomeranian, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdyni
🇵🇱Gdynia, Pomorskie, Poland
Kiepury Clinic
🇵🇱Sosnowiec, Silesian, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Subcarpathian, Poland
Synexus Polska Sp. z o.o. Oddzial w Poznaniu
🇵🇱Poznan, Wielkopolskie, Poland
Instytut Pomnik-Centrum Zdrowia Dziecka
🇵🇱Warszawa, Woj Mazowieckie, Poland
NZOZ "Twoje Zdrowie EL" Sp. z o.o.
🇵🇱Elblag, Poland
Synexus Polska Oddział w Lodzi
🇵🇱Lodz, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
WIP Warsaw IBD Point Profesor Kierkus
🇵🇱Warszawa, Poland
Centrum Medyczne SYNEXUS
🇵🇱Czestochowa, Śląskie, Poland
Caguas Gastroenterology and Hepatology Center, LLC
🇵🇷Caguas, Puerto Rico
Pan American Center for Oncology Trials
🇵🇷Rio Piedras, Puerto Rico
Synexus Polska - Katowicach
🇵🇱Katowice, Śląskie, Poland
Latin Clinical Trial Center
🇵🇷San Juan, Puerto Rico
Spitalul Euroclinic
🇷🇴Bucureti, București, Romania
Wellness clinical Research Vega Baja
🇵🇷Vega Baja, Puerto Rico
Sc Tvm Med Serv
🇷🇴Cluj-Napoca, Cluj, Romania
SC Med Life SA
🇷🇴Bucuresti, Romania
Spitalul Clinic CF 2 Bucuresti
🇷🇴Bucuresti, Romania
S.C. Centrul Medical Medicum SRL
🇷🇴Bucuresti, Romania
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
CCBR Clinical Research
🇷🇴Bucuresti, Romania
Gastromed S.R.L.
🇷🇴Constanta, Romania
Spitalul Clinic Judetean Targu Mures
🇷🇴Targu Mures, Romania
Spitalul Universitar de Urgență București
🇷🇴București, Romania
S.C. Materna Care S.R.L.
🇷🇴Timisoara, Romania
Scientific Centre of Reconstructive and Restorative Surgery
🇷🇺Irkutsk, Irkutskaya Oblast', Russian Federation
Karelia Republican Hospital V.A. Baranova
🇷🇺Petrozavodsk, Kareliya, Respublika, Russian Federation
Rostov State Medical University
🇷🇺Rostov-on-Don, Rostovskaya Oblast', Russian Federation
LLC Medical Center Reavita Med SPb
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Medical and Sanitary Division of Severstal
🇷🇺Cherepovets, Russian Federation
Multidisciplinary Medical Clinic "Anthurium"
🇷🇺Barnaul, Russian Federation
LLC Evimed
🇷🇺Chelyabinsk, Russian Federation
LLC MA New Hospital
🇷🇺Ekaterinburg, Russian Federation
LLC ?Medsanchast No 14?
🇷🇺Moscow, Russian Federation
Clinical Trials Center of Medical Institute
🇷🇺Kaliningrad, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
SIH Kemerovo Regional Clinical Hosptial
🇷🇺Kemerovo, Russian Federation
State Scientific Centre of Coloproctology
🇷🇺Moscow, Russian Federation
Pokrovskaya Municipal Hospital
🇷🇺Saint-Petersburg, Russian Federation
LLC Gastroenterology Centre Expert
🇷🇺Saint-Petersburg, Russian Federation
NonState Healthcare Institution Central Clinical Hospital
🇷🇺Samara, Russian Federation
SBIH City Clinical Hospital #31
🇷🇺Saint-Petersburg, Russian Federation
SPb SBIH "City Polyclinic # 106"
🇷🇺Saint-Petersburg, Russian Federation
Zemun Medical Centre
🇷🇸Zemun, Beograd, Serbia
Clinical Hospital Center Zvezdara
🇷🇸Belgrade, Beograd, Serbia
Academician I.P. Pavlov First St-Petersburg State Medical University
🇷🇺St-Petersburg, Russian Federation
Clinical Center " Dr Dragisa Misovic Dedinje"
🇷🇸Belgrade, Serbia
Clinical Center Nis
🇷🇸Nis, Nišavski Okrug, Serbia
Sremska Mitrovica Health Centre
🇷🇸Sremska Mitrovica, Vojvodina, Serbia
Clinical Center Kragujevac Gastroenterohepatology Clinic
🇷🇸Kragujevac, Serbia
Endomed, s.r.o.
🇸🇰Vranov N. Toplou, Prešovský Kraj, Slovakia
Gastro
🇸🇰Prešov, Prešovský Kraj, Slovakia
FNsP FDRoosevelta Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
CLINIQ, s.r.o
🇸🇰Bratislava, Slovakia
Gastromedic
🇸🇰Nove Zamky, Slovakia
Complejo Hospitalario de Navarra NAVARRABIOMED UNIDAD EC
🇪🇸Pamplona, Navarra, Spain
Centro Medico Teknon - DIGESTIVO
🇪🇸Barcelona, Spain
Hospital Universitari de Girona Dr. Josep Trueta
🇪🇸Girona, Barcelona, Spain
Hospital Reina Sofia
🇪🇸Cordoba, Spain
Instituto de Ciencias Médicas
🇪🇸Alicante, Spain
Hospital De Gran Canaria Dr. Negrin
🇪🇸Las Palmas de Gran Canaria, Spain
Complexo Hospitalario Universitario A Coruña, CHUAC
🇪🇸La Coruña, Spain
Hospital La Princesa
🇪🇸Madrid, Spain
Hospital Universitario Nuestra Señora de la Candelaria
🇪🇸Santa Cruz de Tenerife, Spain
Cantonal Hospital St.Gallen
🇨🇭St. Gallen, Sankt Gallen, Switzerland
Inselspital Bern
🇨🇭Bern, Switzerland
Mersin University Medical Faculty
🇹🇷Yenişehir, Mersin, Turkey
Gastroenterologische Praxis Balsiger, Seibold & Partner
🇨🇭Bern, Switzerland
Antalya Egitim ve Arastırma Hastanesi
🇹🇷Kocaeli, Antalya, Turkey
Acibadem Universitesi - Acibadem Kozyatagi Hastanesi
🇹🇷Kadıkoy, Istanbul, Turkey
Hacettepe University Faculty of Medicine
🇹🇷Ankara, Turkey
Ankara City Hospital
🇹🇷Ankara, Turkey
Gazi University Faculty of Medicine
🇹🇷Ankara, Turkey
Uludag Universitesi
🇹🇷Bursa, Turkey
Trakya University
🇹🇷Edirne, Turkey
Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi Yerleskesi
🇹🇷Istanbul, Turkey
Marmara University Pendik Research and Training Hospital
🇹🇷Istanbul, Turkey
Medicana Kadiköy Hastanesi
🇹🇷Istanbul, Turkey
City Clinical Hospital No. 2
🇺🇦Kharkiv, Kharkivska Oblast, Ukraine
Inonu Universitesi Turgut Ozal Tıp Merkezi
🇹🇷Malatya, Turkey
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
🇺🇦Kiev, Kyiv, Ukraine
Lviv Railway Clinical Hospital
🇺🇦Lviv, Lvivska Oblast, Ukraine
Lviv Regional Endocrinology Dispensary
🇺🇦Lviv, Lvivska Oblast, Ukraine
Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine
🇺🇦Dnipro, Ukraine
RCI Chernivtsi Regional Clinical Hospital
🇺🇦Chernivtsi, Ukraine
Medical Centre of Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV
🇺🇦Kyiv, Ukraine
Kharkiv Regional Council Regional Clinical Hospital
🇺🇦Kharkiv, Ukraine
Ivano-Frankivsk State Medical University
🇺🇦Ivano-Frankivsk, Ukraine
LLC Medbud-Clinic Medical Center
🇺🇦Kyiv, Ukraine
International Institute of Clinical Trials LLC
🇺🇦Kyiv, Ukraine
Communal Enterprise "Odesa Regional Clinical Hospital"
🇺🇦Odesa, Ukraine
Communal institution of the Kyiv Regional Council "Kyiv Regional Clinical Oncology Dispensary"
🇺🇦Kyiv, Ukraine
A. Novak Transcarpathian Regional Clinical Hospital
🇺🇦Uzhgorod, Ukraine
Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU
🇺🇦Vinnytsia, Ukraine
Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrainian Railway
🇺🇦Kyiv, Ukraine
Medical Center "Health Clinic" LLC
🇺🇦Vinnitsa, Ukraine
CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM
🇺🇦Vinnytsia, Ukraine
Zaporozhye City Clinical Hospital #6
🇺🇦Zaporizhzhia, Ukraine
Vinnytsya Regional Clinical Hospital
🇺🇦Vinnytsya, Ukraine
Diacenter LLC
🇺🇦Zaporizhzhia, Ukraine
Addenbrookes Hospital
🇬🇧Cambridge, Cambridgeshire, United Kingdom
Chelsea and Westminster Hospital
🇬🇧Fulham, London, United Kingdom
Synexus Wales Clinical Research Centre
🇬🇧Cardiff, South Glamorgan, United Kingdom
Synexus Manchester Clinical Research Centre
🇬🇧Manchester, Greater Manchester, United Kingdom
Paediatric Clinical Research Facility Royal Hospital for Children and Young People
🇬🇧Edinburgh, United Kingdom
Synexus Midlands Clinical Research Center
🇬🇧Birmingham, Wstmid, United Kingdom
Synexus North East Clinical Research Centre
🇬🇧Hexham, United Kingdom
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
🇬🇧Doncaster, United Kingdom
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Om Research, LLC
🇺🇸Lancaster, California, United States
I.H.S. Health, LLC
🇺🇸Kissimmee, Florida, United States
Ohio Gastroenterology Group Inc.
🇺🇸Dublin, Ohio, United States
University of Texas Medical Branch at Galveston
🇺🇸Galveston, Texas, United States
Whipps Cross University Hospital
🇬🇧London, England, United Kingdom
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Asturias, Spain
Center for Interventional Endoscopy
🇺🇸Orlando, Florida, United States
Endoscopic Research Inc
🇺🇸Orlando, Florida, United States
Orlando Health, Inc
🇺🇸Orlando, Florida, United States
Clintheory Healthcare
🇺🇸Orlando, Florida, United States
Care Access Research - Orlando
🇺🇸Orlando, Florida, United States
Digestive and Liver Center of Florida
🇺🇸Orlando, Florida, United States
University of South Florida
🇺🇸Tampa, Florida, United States
Alliance Clinical Research, LLC
🇺🇸Tampa, Florida, United States
Robley Rex VA Medical Center
🇺🇸Louisville, Kentucky, United States
Gastroenterology Associates of the Piedmont
🇺🇸Winston-Salem, North Carolina, United States
Cliniques Universitaires Saint-Luc
🇧🇪Bruxelles, Brussel, Belgium
Fujita Health University
🇯🇵Toyoake, Aichi, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Jonan-Ku, Fukuoka, Japan
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Nizhny Novgorod Regional Hospital N.A. Semashko
🇷🇺Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu, Kagawa, Japan
Spitalul Pelican
🇷🇴Oradea, Bihor, Romania
Saint-Petersburg City Hospital of Saint Elizabeth
🇷🇺Saint Petersburg, Russian Federation
Amel Med LLC
🇺🇸Austin, Texas, United States
Clinical Research Partners, LLC
🇺🇸Richmond, Virginia, United States
Nola Research Works, LLC
🇺🇸New Orleans, Louisiana, United States
Lovelace Scientific Resources - Albuquerque
🇺🇸Albuquerque, New Mexico, United States
Unc Hospitals
🇺🇸Chapel Hill, North Carolina, United States
Gastroenterology and internal medicine research institute
🇨🇦Edmonton, Alberta, Canada
Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Care Access Research - San Jose
🇺🇸San Jose, California, United States
Qualmedica Research, LLC
🇺🇸Evansville, Indiana, United States
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Austria
Radiant Research
🇺🇸Anderson, South Carolina, United States
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