Long-term Outcomes in Obsessive-Compulsive Disorder Patients Receiving Three Different Modalities of Treatment: SSRIs, Accelerated Deep Transcranial Magnetic Stimulation (aDTMS) with SSRIs, and High Intensity Treatment (HIT)

This prospective study is designed to evaluate the clinical efficacy of a novel High Intensity Treatment (HIT) developed by ANC, for the treatment of OCD. HIT is a combination of pharmacotherapy using Selective Serotonin Reuptake Inhibitors (SSRIs) + accelerated Deep TMS (aDTMS) + concentrated Exposure and Response Prevention (cERP) treatment offered as 5-day intensive phase followed by 6-month follow-up phase. Comparison of outcomes will be performed across three study groups. Group 1- patients on SSRIs alone; group 2- patients on 5-day aDTMS

• SSRIs; group 3- patients receiving HIT. The difference in Yale Brown Obsessive Compulsive Scale (YBOCS) will be the primary outcome measure in all groups, taken at day 5, day 30, 3-month and 6-month follow-up. BrainsWay’s H7 coil will be used for aDTMS administered over 5 days. Adverse effects will be documented after each day of treatment in groups 2 and 3. Secondary outcome measures like Clinical Global Impression-Severity (CGI-S) and WHODAS 2.0 will also be administered.